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Harnessing PD-L1 interface peptide for positron emission tomography imaging of the PD-1 immune checkpoint
https://repo.qst.go.jp/records/80385
https://repo.qst.go.jp/records/8038575d8d39e-8a0c-4f82-9399-bddf85dc62bf
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-08-06 | |||||
| タイトル | ||||||
| タイトル | Harnessing PD-L1 interface peptide for positron emission tomography imaging of the PD-1 immune checkpoint | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Kuan, Hu
× Kuan, Hu× Xie, Lin× Hanyu, Masayuki× Zhang, Yiding× Ma, Xiaohui× Li, Lingyun× Nagatsu, Kotaro× Suzuki, Hisashi× Wang, Weizhi× Ming-Rong, Zhang× Kuan, Hu× Lin, Xie× Masayuki, Hanyu× Zhang, Yiding× Kotaro, Nagatsu× Hisashi, Suzuki× Zhang, Ming-Rong |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Interface peptides that mediate protein-protein interactions (PPI) are a class of important lead compounds for designing PPI inhibitors. However, Their potential as precursors for radiotracers has never been exploited. Here we reported that the interface peptides from programmed death-ligand 1 (PD-L1) can be used in positron emission tomography (PET) imaging of the programmed cell death 1 (PD-1) with high accuracy and sensitivity. Moreover, the performance differentiation between murine PD-L1 derived interface peptide (mPep-1) and human PD-L1 derived interface peptide (hPep-1) as PET tracers for PD-1 unveiled an unprecedented role of a non-critical residue in target binding, highlighting of the significance of PET imaging as a companion diagnostics in drug development. Collectively, this study not only provided a first-of-its-kind peptide-based PET tracer for PD-1 but also conveyed a unique paradigm for developing imaging agents for highly challenging protein targets, which could be used to identify other protein biomarkers involved in the PPI networks. | |||||
| 書誌情報 |
RSC Chemical Biology 巻 2020, 号 1, p. 214-224, 発行日 2020-08 |
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| 出版者 | ||||||
| 出版者 | Royal Society of Chemistry | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2633-0679 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1039/d0cb00070a | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://pubs.rsc.org/en/content/articlelanding/2020/cb/d0cb00070a#!divAbstract | |||||
