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Kinetics of Prostate-Specific Antigen after Carbon Ion Radiotherapy for Prostate Cancer
https://repo.qst.go.jp/records/80282
https://repo.qst.go.jp/records/802828a3481c1-cbb2-4dd2-ab7e-c81185556a13
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-08-04 | |||||
| タイトル | ||||||
| タイトル | Kinetics of Prostate-Specific Antigen after Carbon Ion Radiotherapy for Prostate Cancer | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Dewi Maulany Darwis , Narisa
× Dewi Maulany Darwis , Narisa× Oike, Takahiro× Kawamura, Hidemasa× Kawahara, Masahiro× Kubo, Nobuteru× Sato, Hiro× Miyasaka, Yuhei× Katoh, Hiroyuki× Ishikawa, Hitoshi× Matsui, Hiroshi× Miyazawa, Yoshiyuki× Ito, Kazuto× Suzuki, Kazuhiro× Gondhowiardjo, Soehartati× Nakano, Takashi× Ohno, Tatsuya× Kawamura, Hidemasa× Kubo, Nobuteru× Miyasaka, Yuhei× Ishikawa, Hitoshi× Suzuki, Kazuhiro× Nakano, Takashi× Ohno, Tatsuya |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | This study aimed to first elucidate prostate-specific antigen (PSA) kinetics in prostate cancer patients treated with carbon ion radiotherapy (CIRT). From 2010 to 2015, 131 patients with prostate adenocarcinoma treated with CIRT (57.6 Gy relative biological effectiveness (RBE) in 16 fractions) alone were recruited. PSA was measured at 1, 2, 3, 6, 9, 12, 15, 18, 21, 24, 30, 36, 42, 48, 54, and 60 months post-CIRT. PSA bounce was defined as PSA increase over a cutoff followed by spontaneous decrease to or below the pre-bounce nadir. PSA failure was determined using the Phoenix criteria (nadir + 2.0 ng/mL). As a result, non-failure-associated temporary increase in PSA exhibited two distinct patterns, namely a classical bounce and a surge at one month. PSA bounce of ≥0.2 ng/mL was observed in 55.7% of the patients. Bounce amplitude was <2.0 ng/mL in 97.6% of cases. Bounce occurred significantly earlier than PSA failure. Younger age was a significant predictor of bounce occurrence. Bounce positivity was a significant predictor of favorable 5-year PSA failure-free survival. Meanwhile, a PSA surge of ≥0.2 ng/mL was observed in 67.9% of patients. Surge amplitude was significantly larger than bounce amplitude. Larger prostate volume was a significant predictor of PSA surge occurrence. PSA surge positivity did not significantly predict PSA failure. In summary, PSA bounce was distinguishable from PSA failure with regard to timing of occurrence and amplitude (earlier and lower for bounce, respectively). These data are useful for post-CIRT surveillance of prostate cancer patients. | |||||
| 書誌情報 |
Cancers 巻 12, 号 3, 発行日 2020-03 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2072-6694 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.3390/cancers12030589 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.mdpi.com/2072-6694/12/3/589 | |||||
