WEKO3
アイテム
Excess tau PET ligand retention in elderly patients with major depressive disorder
https://repo.qst.go.jp/records/80253
https://repo.qst.go.jp/records/80253a749b425-523e-4845-a62f-817459c95e8a
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-05-21 | |||||
| タイトル | ||||||
| タイトル | Excess tau PET ligand retention in elderly patients with major depressive disorder | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Moriguchi, Sho
× Moriguchi, Sho× Takahata, Keisuke× Shimada, Hitoshi× Kubota, Manabu× Kitamura, Soichiro× Kimura, Yasuyuki× Tagai, Kenji× Tarumi, Ryosuke× Tabuchi, Hajime× H. Meyer, Jeffrey× Mimura, Masaru× Kawamura, Kazunori× Ming-Rong, Zhang× Murayama, Shigeo× Suhara, Tetsuya× Higuchi, Makoto× Sho, Moriguchi× Keisuke, Takahata× Hitoshi, Shimada× Manabu, Kubota× Soichiro, Kitamura× Yasuyuki, Kimura× Kenji, Tagai× Masaru, Mimura× Kazunori, Kawamura× Zhang, Ming-Rong× Tetsuya, Suhara× Makoto, Higuchi |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Depression is one of the common psychiatric disorders in old age. Major depressive disorder (MDD) has been identified as a risk factor or prodrome for neurodegenerative dementias, suggesting neuropathological overlaps and a continuum between MDD and neurodegenerative disorders. In this study, we examined tau and amyloid-β (Aβ) accumulations in the brains of MDD and healthy controls using positron emission tomography (PET) to explore pathological substrates of this illness. Twenty MDD and twenty age-matched, healthy controls were examined by PET with a tau radioligand, [11C]PBB3, and an Aβ radioligand, [11C]PiB. Radioligand retentions were quantified as a standardized uptake value ratio (SUVR). We also assessed clinical manifestations of the patients using the 17-item Hamilton Depression Scale, the Geriatric Depression Scale, and psychotic symptoms. Mean cortical [11C]PBB3 SUVRs in MDD patients were significantly higher than those of healthy controls. These values were higher in MDD patients with psychotic symptoms than in those without any. The present findings indicate that tau depositions may underlie MDD, and especially in patients with psychotic symptoms. PET detection of tau accumulations may provide mechanistic insights into neuronal dysfunctions in these cases and could serve as predictions of their clinical consequences. | |||||
| 書誌情報 |
Molecular Psychiatry 巻 26, p. 5856-5863, 発行日 2020-07 |
|||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1359-4184 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 32606373 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1038/s41380-020-0766-9 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.nature.com/articles/s41380-020-0766-9 | |||||
