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Genetically fused charged peptides induce rapid crystallization of protein.
https://repo.qst.go.jp/records/80142
https://repo.qst.go.jp/records/801422025df61-8384-4ae1-bebc-61a5797ac306
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-01-21 | |||||
| タイトル | ||||||
| タイトル | Genetically fused charged peptides induce rapid crystallization of protein. | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
南畑, 孝介(東大院・工)
× 南畑, 孝介(東大院・工)× 塚本, 啓介(東大院・工)× 安達, 基泰× 清水, 瑠美× Masahiro, Mishina(東大院・工)× 長棟輝行(東大院・工)× Adachi, Motoyasu× Shimizu, Rumi |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Protein crystals are important materials in X-ray crystallography to reveal the 3D structure of proteins but they are also attractive as a reaction vessel or template for nanomaterials; however, crystallizing protein is extremely difficult, hampering such utilization of protein crystals. We serendipitously discovered that streptavidin crystals form instantaneously upon mixing streptavidins with positively or negatively charged peptides at their C-termini. Hybrid crystals of streptavidin with charged oligo-peptides, oligo-DNA, and dendrimers were also obtained via interaction between the charged peptides on streptavidins and the small charged molecules. This technique uses simple electrostatic interaction between the charged peptides; therefore it should be applicable to many proteins, defying the stereotypes about protein crystallization and facilitating the use of protein crystals as functional materials. | |||||
| 書誌情報 |
Chemical Communications 巻 56, 号 27, p. 3891-3894, 発行日 2020-04 |
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| 出版者 | ||||||
| 出版者 | The Royal Society of Chemistry | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1359-7345 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1039/c9cc09529b | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://pubs.rsc.org/en/content/articlelanding/2020/cc/c9cc09529b#!divAbstract | |||||
