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DR-SIP: Predicting the Quaternary Structures of Homo-oligomeric Transmembrane Proteins
https://repo.qst.go.jp/records/80124
https://repo.qst.go.jp/records/80124f80cc2ff-2a85-4ec0-a487-995e894f30a6
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-06-29 | |||||
| タイトル | ||||||
| タイトル | DR-SIP: Predicting the Quaternary Structures of Homo-oligomeric Transmembrane Proteins | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Soon Chan, Wai
× Soon Chan, Wai× Soon Chan, Wai |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Proteins commonly form quaternary complexes to perform their biological functions. The main computational method used to predict these complexes is molecular docking which is mostly limited to predicting dimers. Here we introduce a new docking protocol, Distance Restraints- and Cyclic Symmetry-Imposed Packing (DR-SIP), which can predict the quaternary structures of homo-oligomeric transmembrane proteins (HoTPs) of any size (dimers or larger) without prior-knowledge of its native size. DR-SIP is able to recover 52.6% and 76.3% of HoTPs within the top-20 poses when given/not-given the complexes’ native size, respectively. Predictions can be further improved by making use of distance-based experimental data such as those from single-molecule FRET (smFRET). | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第58回 日本生物物理学会年会 | |||||
| 発表年月日 | ||||||
| 日付 | 2020-09-16 | |||||
| 日付タイプ | Issued | |||||
