{"_buckets": {"deposit": "8598e067-3e5c-4932-9f92-407c7ef42ef5"}, "_deposit": {"created_by": 1, "id": "80110", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "80110"}, "status": "published"}, "_oai": {"id": "oai:repo.qst.go.jp:00080110", "sets": ["1"]}, "author_link": ["873860", "873847", "873849", "873844", "873858", "873853", "873857", "873840", "873845", "873862", "873851", "873843", "873852", "873861", "873855", "873859", "873842", "873846", "873850", "873863", "873848", "873841", "873856", "873854"], "item_8_biblio_info_7": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2020-05", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "27", "bibliographicVolumeNumber": "61", "bibliographic_titles": [{"bibliographic_title": "Tetrahedron Letters"}]}]}, "item_8_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Positive allosteric modulators of muscarinic acetylcholine receptor subtype 4 have been identified as promising activators for the treatment of neurological disorders and neurodegenerative diseases, including schizophrenia, Alzheimer\u0027s disease (AD) and dementia with Lewy bodies (DLB). Herein we report the synthesis and preliminary evaluation of a 18F-labeled positron emission tomography ligand based on a M4 activator (7). 18F-Isotopologue of 7 was prepared in a reasonable radiochemical yield with high radiochemical purity (\u003e99%) and high molar activity (\u003e37 GBq/µmol). In vitro autoradiography studies indicated that the ligand possessed moderate in vitro specific binding. Dynamic PET studies in vivo demonstrated that [18F]7 (also named as [18F]M4R-1911) failed to cross the blood–brain barrier. Therefore, further chemical scaffold optimization in chemotype of 7 is necessary to overcome limited brain permeability and improve specific binding.", "subitem_description_type": "Abstract"}]}, "item_8_publisher_8": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Elsevier"}]}, "item_8_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1016/j.tetlet.2020.152060", "subitem_relation_type_select": "DOI"}}]}, "item_8_relation_17": {"attribute_name": "関連サイト", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "https://www.sciencedirect.com/science/article/pii/S0040403920305062", "subitem_relation_type_select": "URI"}}]}, "item_8_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0040-4039", "subitem_source_identifier_type": "ISSN"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "metadata only access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_14cb"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Deng, Xiaoyun"}], "nameIdentifiers": [{"nameIdentifier": "873840", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Zhang, Yiding"}], "nameIdentifiers": [{"nameIdentifier": "873841", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Rong, Jian"}], "nameIdentifiers": [{"nameIdentifier": "873842", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kumata, Katsushi"}], "nameIdentifiers": [{"nameIdentifier": "873843", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shao, Tuo"}], "nameIdentifiers": [{"nameIdentifier": "873844", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Wang, Gangqiang"}], "nameIdentifiers": [{"nameIdentifier": "873845", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hatori, Akiko"}], "nameIdentifiers": [{"nameIdentifier": "873846", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Mori, Wakana"}], "nameIdentifiers": [{"nameIdentifier": "873847", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yu, Qingzhen"}], "nameIdentifiers": [{"nameIdentifier": "873848", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kuan, Hu"}], "nameIdentifiers": [{"nameIdentifier": "873849", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Fujinaga, Masayuki"}], "nameIdentifiers": [{"nameIdentifier": "873850", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shao, Yihan"}], "nameIdentifiers": [{"nameIdentifier": "873851", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Josephson, Lee"}], "nameIdentifiers": [{"nameIdentifier": "873852", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sun, Shaofa"}], "nameIdentifiers": [{"nameIdentifier": "873853", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ming-Rong, Zhang"}], "nameIdentifiers": [{"nameIdentifier": "873854", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Liang, Huan"}], "nameIdentifiers": [{"nameIdentifier": "873855", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Zhang, Yiding", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "873856", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kumata, Katsushi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "873857", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hatori, Akiko", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "873858", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Mori, Wakana", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "873859", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kuan, Hu", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "873860", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Fujinaga, Masayuki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "873861", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ming-Rong, Zhang", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "873862", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Liang, Huan", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "873863", "nameIdentifierScheme": "WEKO"}]}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Synthesis and preliminary evaluation of 18F-labeled 1-(6,7-dimethyl-4-(methylamino)-1,3-dihydro-2H-pyrrolo[3,4-c]pyridin-2-yl)-2-(trans-2-(6-fluoropyridin-3-yl)cyclopropyl)ethan-1-one for imaging muscarinic acetylcholine receptor subtype 4", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Synthesis and preliminary evaluation of 18F-labeled 1-(6,7-dimethyl-4-(methylamino)-1,3-dihydro-2H-pyrrolo[3,4-c]pyridin-2-yl)-2-(trans-2-(6-fluoropyridin-3-yl)cyclopropyl)ethan-1-one for imaging muscarinic acetylcholine receptor subtype 4"}]}, "item_type_id": "8", "owner": "1", "path": ["1"], "permalink_uri": "https://repo.qst.go.jp/records/80110", "pubdate": {"attribute_name": "公開日", "attribute_value": "2020-06-24"}, "publish_date": "2020-06-24", "publish_status": "0", "recid": "80110", "relation": {}, "relation_version_is_last": true, "title": ["Synthesis and preliminary evaluation of 18F-labeled 1-(6,7-dimethyl-4-(methylamino)-1,3-dihydro-2H-pyrrolo[3,4-c]pyridin-2-yl)-2-(trans-2-(6-fluoropyridin-3-yl)cyclopropyl)ethan-1-one for imaging muscarinic acetylcholine receptor subtype 4"], "weko_shared_id": -1}