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Biological washout modelling for in-beam PET: rabbit brain
https://repo.qst.go.jp/records/80103
https://repo.qst.go.jp/records/80103f4ae9cf3-2a18-4d69-b575-ed7fcebf1fe6
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-06-19 | |||||
| タイトル | ||||||
| タイトル | Biological washout modelling for in-beam PET: rabbit brain | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Toramatsu, Chie
× Toramatsu, Chie× Mohammadi, Akram× Wakizaka, Hidekatsu× Seki, Chie× Nishikido, Fumihiko× Sato, Shinji× Takahashi, Miwako× Karasawa, Kumiko× Hirano, Yoshiyuki× Yamaya, Taiga× Chie, Toramatsu× Mohammadi, Akram× Hidekatsu, Wakizaka× Chie, Seki× Fumihiko, Nishikido× Shinji, Sato× Miwako, Takahashi× Kumiko, Karasawa× Yoshiyuki, Hirano× Taiga, Yamaya |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Positron emission tomography (PET) has been used for dose verification in charged particle therapy. The causes of washout of positron emitters by physiological functions should be clarified for accurate dose verification. In this study, we visualized the distribution of irradiated radioactive beams, 11C and 15O beams, in the rabbit whole-body using our original depth-of-interaction (DOI)-PET prototype to add basic data for biological washout effect correction. Time activity curves of the irradiated field and organs were measured immediately after the irradiations. All data were corrected for physical decay before further analysis. We also collected expired gas of the rabbit during beam irradiation and the energy spectrum was measured with a germanium detector. Irradiated radioactive beams into the brain were distributed to the whole body due to the biological washout process, and the implanted 11C and 15O ions were concentrated in the regions which had high blood volume. The 11C-labelled 11CO2 was detected in expired gas under the 11C beam irradiation, while no significant signal was detected under the 15O beam irradiation as a form of C15O2. Results suggested that the implanted 11C ions form molecules that diffuse out to the whole body by undergoing perfusion, then, they are incorporated into the blood-gas exchange in the respiratory system. This study provides basic data for modelling of the biological washout effect. |
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| 書誌情報 |
Physics in Medicine & Biology 巻 65, 号 10, p. 105011-1-105011-12, 発行日 2020-05 |
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| 出版者 | ||||||
| 出版者 | IOP Publishing | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0031-9155 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 32235057 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1088/1361-6560/ab8532 | |||||
| 関連サイト | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1088/1361-6560/ab8532 | |||||
