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Feasibility study of a PET-only amyloid quantification method: a comparison with visual interpretation
https://repo.qst.go.jp/records/80099
https://repo.qst.go.jp/records/80099e4ddc3dc-c3a9-4c81-9d53-53a59c97e56b
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-06-22 | |||||
| タイトル | ||||||
| タイトル | Feasibility study of a PET-only amyloid quantification method: a comparison with visual interpretation | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Shimokawa, Natsumi
× Shimokawa, Natsumi× Akamatsu, Go× Kadosaki, Miyako× Sasaki, Masayuki× Akamatsu, Go |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Objective: Visual evaluation is the standard for amyloid positron emission tomography (PET) examination, though the result depends upon the physician’s subjective review of the images. Therefore, it is expected that objective quantitative evaluation is useful for image interpretation. In this study, we examined the usefulness of the quantitative evaluation of amyloid PET using a PET-only quantification method in comparison with visual evaluation. Methods: In this study we retrospectively investigated a total of 166 individuals, including 58 cognitively normal controls, 62 individuals with mild cognitive impairment, and 46 individuals with early Alzheimer’s disease. They underwent 11C-Pitts- burgh compound-B (PiB) PET examination through the Japanese Alzheimer’s Disease Neuroimaging Initiative (J-ADNI). Amyloid accumulation in cerebral cortices was assessed using visual and quantitative methods. The quantitative evaluation was performed using the adaptive template method and empirically PiB-prone region of interest, and the standardized uptake value ratio (SUVR) in each area was obtained. Results: Visual evaluation and SUVR were significantly correlated in the cerebral cortices (ρ = 0.85–0.87; p < 0.05). In visual evaluation, sensitivity, specificity, and accuracy were 78%, 76%, and 77%, respectively. Meanwhile, for quantitative evalua- tion, sensitivity, specificity, and accuracy were 77%, 79%, and 78% in mean cortical SUVR (mcSUVR) and 79%, 79%, and 79% in maximum SUVR (maxSUVR), respectively. Conclusion: The PET-only quantification method provided a concordant result with visual evaluation and was considered useful for amyloid PET. | |||||
| 書誌情報 |
Annals of Nuclear Medicine 巻 34, p. 629-635, 発行日 2020-06 |
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| 出版者 | ||||||
| 出版者 | Springer Nature | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0914-7187 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 32535743 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1007/s12149-020-01486-3 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://link.springer.com/article/10.1007/s12149-020-01486-3 | |||||
