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Nasal vaccine delivery attenuates brain pathology and cognitive impairment in tauopathy model mice
https://repo.qst.go.jp/records/80033
https://repo.qst.go.jp/records/80033f3f82a7a-f56c-422e-9ea8-513f36a1efee
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-02-21 | |||||
| タイトル | ||||||
| タイトル | Nasal vaccine delivery attenuates brain pathology and cognitive impairment in tauopathy model mice | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Takeuchi, Hiroki
× Takeuchi, Hiroki× Imamura, Keiko× Ji, Bin× Tsukita, Kayoko× Enami, Takako× Takao, Keizo× Miyakawa, Tsuyoshi× Hasegawa, Masato× Sahara, Naruhiko× Iwata, Nobuhisa× Inoue, Makoto× Hara, Hideo× Tabira, Takeshi× Ono, Maiko× Trojanowski, John× Lee, Virginia× Takahashi, Ryosuke× Suhara, Tetsuya× Higuchi, Makoto× Inoue, Haruhisa× Ji, Bin× Sahara, Naruhiko× Ono, Maiko× Suhara, Tetsuya× Higuchi, Makoto× Inoue, Haruhisa |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Pathological aggregates of tau proteins accumulate in the brains of neurodegenerative tauopathies including Alzheimer’s disease and frontotemporal lobar degeneration (FTLD-tau). Although immunotherapies of these disorders against tau are emerging, it is unknown whether nasal delivery, which offers many benefits over traditional approaches to vaccine administration, is effective or not for tauopathy. Here, we developed vaccination against a secreted form of pathological tau of FTLD-tau using a Sendai virus (SeV) vector infectious to host nasal mucosa, a key part of the immune system. Tau vaccines given as nasal drops induced tissue tau-immunoreactive antibody production and ameliorated cognitive impairment in FTLD-tau model mice. In vivo imaging and postmortem neuropathological assays demonstrated the suppression of phosphorylated tau accumulation, neurotoxic gliosis and neuronal loss in the hippocampus of immunized mice. These findings suggest that nasal vaccine delivery may provide a therapeutic opportunity for a broad range of populations with human tauopathy. | |||||
| 書誌情報 |
npj Vaccines 巻 5, 号 28, 発行日 2020-03 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2059-0105 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 32219000 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1038/s41541-020-0172-y | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.nature.com/articles/s41541-020-0172-y | |||||
