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Generation of Localized Highly Concentrated Hydrogen Peroxide Clusters in Water by X-Rays
https://repo.qst.go.jp/records/79973
https://repo.qst.go.jp/records/79973c4b2836c-034c-4a3c-9a03-64a1b29221ed
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2019-10-28 | |||||
| タイトル | ||||||
| タイトル | Generation of Localized Highly Concentrated Hydrogen Peroxide Clusters in Water by X-Rays | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Ueno, Megumi
× Ueno, Megumi× Nakanishi, Ikuo× Ken-ichiro, Matsumoto× Megumi, Ueno× Ikuo, Nakanishi× Kenichiro, Matsumoto |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The formation of highly concentrated hydrogen peroxide (H2O2) clusters (localized circumstance) in an aqueous solution during X-ray irradiation was demonstrated. The relationship between H2O2 concentration and hydrogen donor-independent reduction of nitroxyl radicals was examined. The method to measure the distance between the clusters (localized circumstance) was assessed by comparing the simulation and the experimental results. Reaction mixtures containing a nitroxyl redox probe, 4-hydroxyl-2,2,6,6-tetramethylpiperidine-N-oxyl (TEMPOL) and 3-carbamoyl-2,2,5,5-tetramethylpyrrolidine-N-oxyl (CmP) at 0.1 mM were prepared containing several different concentrations (1.0 mM‒9.8 M) of H2O2. The reaction mixture was irradiated by 12000 μW/cm2 UVB for 2 min, and reduction of the electron paramagnetic resonance (EPR) signal of the nitroxyl radicals was measured. An aliquot (2 µL) of 200 mM K3[Fe(CN)6] or FeCl3 solution was added to 200 µL of the reaction mixture, and the time course of the EPR signal of the nitroxyl radicals was measured. To estimate the distance between the H2O2 clusters, a series of nitroxyl radical solutions with several different concentrations (0.06 μM‒2.28 mM) was irradiated with X-rays, and the degree of reduction of nitroxyl radicals in each sample was measured. UVB, K3[Fe(CN)6], or FeCl3-induced EPR signal loss of the nitroxyl radicals was observed with H2O2 concentrations greater than 10 mM or 100 mM, respectively. The EPR signal loss of nitroxyl radicals, TEMPOL or CmP may occur in highly concentrated H2O2 circumstances after oxidative stimulation. Plotting the X-ray-induced reduction of nitroxyl radicals versus their density revealed the high-concentration H2O2 clusters to be separated by 40‒47 nm. Ionizing irradiation of an aqueous solution create a localized highly concentrated H2O2 environment. | |||||
| 書誌情報 |
Free Radical Research 巻 54, 号 5, p. 360-372, 発行日 2020-05 |
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| 出版者 | ||||||
| 出版者 | Taylor & Francis | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1029-2470 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 32450709 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1080/10715762.2020.1774574 | |||||
| 関連サイト | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1080/10715762.2020.1774574 | |||||
