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  1. 原著論文

Overlapping but Asymmetrical Relationships Between Schizophrenia and Autism Revealed by Brain Connectivity.

https://repo.qst.go.jp/records/79912
https://repo.qst.go.jp/records/79912
35698492-9f04-495f-9fa6-0b157e600808
Item type 学術雑誌論文 / Journal Article(1)
公開日 2020-04-23
タイトル
タイトル Overlapping but Asymmetrical Relationships Between Schizophrenia and Autism Revealed by Brain Connectivity.
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 Yoshihara, Yujiro

× Yoshihara, Yujiro

WEKO 888627

Yoshihara, Yujiro

Search repository
Lisi, Giuseppe

× Lisi, Giuseppe

WEKO 888628

Lisi, Giuseppe

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Yahata, Noriaki

× Yahata, Noriaki

WEKO 888629

Yahata, Noriaki

Search repository
Fujino, Junya

× Fujino, Junya

WEKO 888630

Fujino, Junya

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Matsumoto, Yukiko

× Matsumoto, Yukiko

WEKO 888631

Matsumoto, Yukiko

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Miyata, Jun

× Miyata, Jun

WEKO 888632

Miyata, Jun

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Gen-Ichi, Sugihara

× Gen-Ichi, Sugihara

WEKO 888633

Gen-Ichi, Sugihara

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Shin-Ichi, Urayama

× Shin-Ichi, Urayama

WEKO 888634

Shin-Ichi, Urayama

Search repository
Kubota, Manabu

× Kubota, Manabu

WEKO 888635

Kubota, Manabu

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Yamashita, Masahiro

× Yamashita, Masahiro

WEKO 888636

Yamashita, Masahiro

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Hashimoto, Ryuichiro

× Hashimoto, Ryuichiro

WEKO 888637

Hashimoto, Ryuichiro

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Ichikawa, Naho

× Ichikawa, Naho

WEKO 888638

Ichikawa, Naho

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Cahn, Weipke

× Cahn, Weipke

WEKO 888639

Cahn, Weipke

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E M van Haren, Neeltje

× E M van Haren, Neeltje

WEKO 888640

E M van Haren, Neeltje

Search repository
Mori, Susumu

× Mori, Susumu

WEKO 888641

Mori, Susumu

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Okamoto, Yasumasa

× Okamoto, Yasumasa

WEKO 888642

Okamoto, Yasumasa

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Kasai, Kiyoto

× Kasai, Kiyoto

WEKO 888643

Kasai, Kiyoto

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Kato, Nobumasa

× Kato, Nobumasa

WEKO 888644

Kato, Nobumasa

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Imamizu, Hiroshi

× Imamizu, Hiroshi

WEKO 888645

Imamizu, Hiroshi

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René, S Kahn

× René, S Kahn

WEKO 888646

René, S Kahn

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Sawa, Akira

× Sawa, Akira

WEKO 888647

Sawa, Akira

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Kawato, Mitsuo

× Kawato, Mitsuo

WEKO 888648

Kawato, Mitsuo

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Murai, Toshiya

× Murai, Toshiya

WEKO 888649

Murai, Toshiya

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Morimoto, Jun

× Morimoto, Jun

WEKO 888650

Morimoto, Jun

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Takahashi, Hidehiko

× Takahashi, Hidehiko

WEKO 888651

Takahashi, Hidehiko

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Yahata, Noriaki

× Yahata, Noriaki

WEKO 888652

en Yahata, Noriaki

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Kubota, Manabu

× Kubota, Manabu

WEKO 888653

en Kubota, Manabu

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Takahashi, Hidehiko

× Takahashi, Hidehiko

WEKO 888654

en Takahashi, Hidehiko

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抄録
内容記述タイプ Abstract
内容記述 Although the relationship between schizophrenia spectrum disorder (SSD) and autism spectrum disorder (ASD) has long been debated, it has not yet been fully elucidated. The authors quantified and visualized the relationship between ASD and SSD using dual classifiers that discriminate patients from healthy controls (HCs) based on resting-state functional connectivity magnetic resonance imaging. To develop a reliable SSD classifier, sophisticated machine-learning algorithms that automatically selected SSD-specific functional connections were applied to Japanese datasets from Kyoto University Hospital (N = 170) including patients with chronic-stage SSD. The generalizability of the SSD classifier was tested by 2 independent validation cohorts, and 1 cohort including first-episode schizophrenia. The specificity of the SSD classifier was tested by 2 Japanese cohorts of ASD and major depressive disorder. The weighted linear summation of the classifier's functional connections constituted the biological dimensions representing neural classification certainty for the disorders. Our previously developed ASD classifier was used as ASD dimension. Distributions of individuals with SSD, ASD, and HCs s were examined on the SSD and ASD biological dimensions. We found that the SSD and ASD populations exhibited overlapping but asymmetrical patterns in the 2 biological dimensions. That is, the SSD population showed increased classification certainty for the ASD dimension but not vice versa. Furthermore, the 2 dimensions were correlated within the ASD population but not the SSD population. In conclusion, using the 2 biological dimensions based on resting-state functional connectivity enabled us to discover the quantified relationships between SSD and ASD.
書誌情報 Schizophrenia bulletin

巻 46, 号 5, p. 1210-1218, 発行日 2020-04
出版者
出版者 Oxford University Press
ISSN
収録物識別子タイプ ISSN
収録物識別子 0586-7614
PubMed番号
識別子タイプ PMID
関連識別子 32300809
DOI
識別子タイプ DOI
関連識別子 10.1093/schbul/sbaa021
関連サイト
識別子タイプ URI
関連識別子 https://academic.oup.com/schizophreniabulletin/article-abstract/46/5/1210/5815410?redirectedFrom=fulltext
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