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Overlapping but Asymmetrical Relationships Between Schizophrenia and Autism Revealed by Brain Connectivity.
https://repo.qst.go.jp/records/79912
https://repo.qst.go.jp/records/7991235698492-9f04-495f-9fa6-0b157e600808
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-04-23 | |||||
| タイトル | ||||||
| タイトル | Overlapping but Asymmetrical Relationships Between Schizophrenia and Autism Revealed by Brain Connectivity. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Yoshihara, Yujiro
× Yoshihara, Yujiro× Lisi, Giuseppe× Yahata, Noriaki× Fujino, Junya× Matsumoto, Yukiko× Miyata, Jun× Gen-Ichi, Sugihara× Shin-Ichi, Urayama× Kubota, Manabu× Yamashita, Masahiro× Hashimoto, Ryuichiro× Ichikawa, Naho× Cahn, Weipke× E M van Haren, Neeltje× Mori, Susumu× Okamoto, Yasumasa× Kasai, Kiyoto× Kato, Nobumasa× Imamizu, Hiroshi× René, S Kahn× Sawa, Akira× Kawato, Mitsuo× Murai, Toshiya× Morimoto, Jun× Takahashi, Hidehiko× Yahata, Noriaki× Kubota, Manabu× Takahashi, Hidehiko |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Although the relationship between schizophrenia spectrum disorder (SSD) and autism spectrum disorder (ASD) has long been debated, it has not yet been fully elucidated. The authors quantified and visualized the relationship between ASD and SSD using dual classifiers that discriminate patients from healthy controls (HCs) based on resting-state functional connectivity magnetic resonance imaging. To develop a reliable SSD classifier, sophisticated machine-learning algorithms that automatically selected SSD-specific functional connections were applied to Japanese datasets from Kyoto University Hospital (N = 170) including patients with chronic-stage SSD. The generalizability of the SSD classifier was tested by 2 independent validation cohorts, and 1 cohort including first-episode schizophrenia. The specificity of the SSD classifier was tested by 2 Japanese cohorts of ASD and major depressive disorder. The weighted linear summation of the classifier's functional connections constituted the biological dimensions representing neural classification certainty for the disorders. Our previously developed ASD classifier was used as ASD dimension. Distributions of individuals with SSD, ASD, and HCs s were examined on the SSD and ASD biological dimensions. We found that the SSD and ASD populations exhibited overlapping but asymmetrical patterns in the 2 biological dimensions. That is, the SSD population showed increased classification certainty for the ASD dimension but not vice versa. Furthermore, the 2 dimensions were correlated within the ASD population but not the SSD population. In conclusion, using the 2 biological dimensions based on resting-state functional connectivity enabled us to discover the quantified relationships between SSD and ASD. | |||||
| 書誌情報 |
Schizophrenia bulletin 巻 46, 号 5, p. 1210-1218, 発行日 2020-04 |
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| 出版者 | ||||||
| 出版者 | Oxford University Press | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0586-7614 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 32300809 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1093/schbul/sbaa021 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://academic.oup.com/schizophreniabulletin/article-abstract/46/5/1210/5815410?redirectedFrom=fulltext | |||||
