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A common allosteric mechanism regulates homeostatic inactivation of auxin and gibberellin
https://repo.qst.go.jp/records/79901
https://repo.qst.go.jp/records/7990147517c53-ca89-4b0e-be6f-3a40ff47158b
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2019-09-04 | |||||
| タイトル | ||||||
| タイトル | A common allosteric mechanism regulates homeostatic inactivation of auxin and gibberellin | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Takehara, Sayaka
× Takehara, Sayaka× Sakuraba, Shun× Mikami, Bunzo× Yoshida, Hideki× Yoshimura, Hisako× Itho, Aya× Endo, Masaki× Watanabe, Nobuhisa× Nagae, Takayuki× Matsuoka, Makoto× Miyako, Ueguchi-Tanaka× Sakuraba, Shun |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | X-ray structural analysis of gibberellin (GA) and auxin inactivation enzymes GA 2-oxidase 3 (GA2ox3) and auxin dioxygenase was used to elucidate the post-translational regulatory mechanism of homeostasis of growth phytohormones in rice. Results revealed that both enzymes form multimers by bridging their substrates, GA4 and indole acetic acid (IAA), at their interface regions. Further functional analyses revealed that multimerization of these enzymes gradually proceeds with increasing GA4 and IAA concentrations, and multimerized enzymes have much higher specific activities than monomer forms, a system that should favour homeostasis maintenance of these phytohormones. Molecular dynamic analysis explained the mechanism responsible for increasing GA2ox3 activity by multimerization—GA4 in the interface of oligomerized GA2ox3s can enter the active site with a low energy barrier. In summary, we report that the homeostatic systems for maintaining GA and IAA levels, based on the same allosteric mechanism, developed independently at the times when seed plants and angiosperms appeared. | |||||
| 書誌情報 |
Nature communications 巻 11, 発行日 2020-05 |
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| 出版者 | ||||||
| 出版者 | Springer Nature | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2041-1723 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1038/s41467-020-16068-0 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.nature.com/articles/s41467-020-16068-0 | |||||
