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18F-PM-PBB3 (18F-APN-1607) uptake associates with plasma NfL level and motor disability in patients with progressive supranuclear palsy
https://repo.qst.go.jp/records/79772
https://repo.qst.go.jp/records/7977209f96b18-6410-49d1-b42a-84c479e3f060
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-04-01 | |||||
| タイトル | ||||||
| タイトル | 18F-PM-PBB3 (18F-APN-1607) uptake associates with plasma NfL level and motor disability in patients with progressive supranuclear palsy | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Shimada, Hitoshi
× Shimada, Hitoshi× Matsuoka, Kiwamu× Kubota, Manabu× Takahata, Keisuke× Takado, Yuhei× Seki, Chie× Ono, Maiko× Sahara, Naruhiko× Kawamura, Kazunori× Ming-Rong, Zhang× Higuchi, Makoto× Shimada, Hitoshi× Matsuoka, Kiwamu× Kubota, Manabu× Takahata, Keisuke× Takado, Yuhei× Seki, Chie× Ono, Maiko× Sahara, Naruhiko× Kawamura, Kazunori× Ming-Rong, Zhang× Higuchi, Makoto |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background and Aims: Our previous studies demonstrated that 18F-PM-PBB3 (18F-APN-1607) uptake may reflect characteristic distributions of tau pathologies in 4-repeat tauopathies including progressive supranuclear palsy (PSP). The present study aimed to investigate the association among 18F-PM-PBB3 uptake, neurodegenerative biomarker level, and clinical symptoms in PSP with Richardson syndrome (PSP-RS) patients. Methods: 21 patients with probable PSP-RS underwent PET scans with 18F-PM-PBB3 and 11C-PiB for estimating regional tau and Aβ deposition. Plasma neurofilament light chain (NfL) levels were also checked as a neurodegenerative biomarker. Parametric 18F-PM-PBB3- and 11C-PiB- images were generated by voxel-based calculation of the standardized uptake value ratio (SUVR) to the cerebellar cortex. Three patients, who were diagnosed as amyloid-positive by visual assessment of 11C-PiB SUVR image, and two patients lacking some data (PET or NfL) were excluded. Finally, the other 18PiB-negative PSP-RS patients were included for further analyses. Regional 18F-PM-PBB3 SUVR was estimated in dentate, midbrain, subthalamus, striatum, pre- and post-central gyri in addition to PSP tau PET meta-ROI. We assessed Pearson’s correlation of regional 18F-PM-PBB3 SUVR with plasma NfL levels and motor severity assessed by PSP rating scale. Results: Plasma NfL levels showed positive correlation with 18F-PM-PBB3 SUVR in striatum, pre- and post-central gyri as well as PSP tau PET meta-ROI (r = 0.77, 0.98, 0.95, and 0.78; p < 0.05, followed by Bonferroni correction), and a trend toward significance in midbrain and dentate (r = 0.68 and 0.51; p = 0.008 and 0.043, without multiple comparison). PSP rating scale score positively correlated with plasma NFL (r = 0.73; p < 0.01, followed by Bonferroni correction), and there were trends towards significance between PSP rating scale and 18F-PM-PBB3 SUVR in midbrain and PSP tau PET meta-ROI (r = 0.66 and 0.65; p = 0.01 and 0.03, without multiple comparison). Conclusions: Accumulations of PM-PBB3 may reflect neurotoxic tau pathologies in PSP-RS, in tight association with clinical symptoms. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Takeda Expert Conference on Parkinson's Disease 2020 | |||||
| 発表年月日 | ||||||
| 日付 | 2020-02-02 | |||||
| 日付タイプ | Issued | |||||
