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Individual response of humans to ionising radiation: governing factors and importance for radiological protection
https://repo.qst.go.jp/records/79597
https://repo.qst.go.jp/records/79597f8b63521-22f7-486b-a436-b1e6bcb1c638
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-03-19 | |||||
| タイトル | ||||||
| タイトル | Individual response of humans to ionising radiation: governing factors and importance for radiological protection | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
E. Applegate, Kimberly
× E. Applegate, Kimberly× Werner, Rühm× Wojcik, Andrzej× Bourguignon, Michael× Brenner, Alina× Hamasaki, Kanya× Imai, Takashi× Imaizumi, Misa× Imaoka, Tatsuhiko× Kakinuma, Shizuko× Kamada, Tadashi× Nishimura, Mayumi× Okonogi, Noriyuki× Ozasa, Kotaro× Claudia, E. Rübe× Sadakane, Atsuko× Sakata, Ritsu× Shimada, Yoshiya× Yoshida, Kengo× Imai, Takashi× Imaoka, Tatsuhiko× Kakinuma, Shizuko× Kamada, Tadashi× Nishimura, Mayumi× Okonogi, Noriyuki× Shimada, Yoshiya |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Tissue reactions and stochastic effects after exposure to ionising radiation are variable between individuals but the factors and mechanisms governing individual responses are not well understood. Individual responses can be measured at different levels of biological organization and using different endpoints following varying doses of radiation, including: cancers, non-cancer diseases and mortality in the whole organism; normal tissue reactions after exposures; and, cellular endpoints such as chromosomal damage and molecular alterations. There is no doubt that many factors influence the responses of people to radiation to different degrees. In addition to the obvious general factors of radiation quality, dose, dose rate and the tissue (sub)volume irradiated, recognized and potential determining factors include age, sex, life style (e.g., smoking, diet, possibly body mass index), environmental factors, genetics and epigenetics, stochastic distribution of cellular events, and systemic comorbidities such as diabetes or viral infections. Genetic factors are commonly thought to be a substantial contributor to individual response to radiation. Apart from a small number of rare monogenic diseases such as ataxia telangiectasia, the inheritance of an abnormally responsive phenotype among a population of healthy individuals does not follow a classical Mendelian inheritance pattern. Rather it is considered to be a multi-factorial, complex trait. | |||||
| 書誌情報 |
Radiation and Environmental Biophysics 巻 59, p. 185-209, 発行日 2020-03 |
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| 出版者 | ||||||
| 出版者 | Springer | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0301-634X | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1007/s00411-020-00837-y | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://link.springer.com/article/10.1007%2Fs00411-020-00837-y | |||||
