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Cereblon Control of Zebrafish Brain Size by Regulation of Neural Stem Cell Proliferation.
https://repo.qst.go.jp/records/79162
https://repo.qst.go.jp/records/79162576013c7-57d3-4a3d-8ba2-68a79f1ccd42
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-03-03 | |||||
| タイトル | ||||||
| タイトル | Cereblon Control of Zebrafish Brain Size by Regulation of Neural Stem Cell Proliferation. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Ando, Hideki
× Ando, Hideki× Sato, Tomomi× Ito, Takumi× Yamamoto, Junichi× Sakamoto, Satoshi× Nitta, Nobuhiro× Tomoko, Asatsuma-Okumura× Shimizu, Nobuyuki× Mizushima, Ryota× Aoki, Ichio× Imai, Takeshi× Yamaguchi, Yuki× J Berk, Arnold× Handa, Hiroshi× Nobuhiro, Nitta× Ichio, Aoki |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Thalidomide is a teratogen that causes multiple malformations in the developing baby through its interaction with cereblon (CRBN), a substrate receptor subunit of the CRL4 E3 ubiquitin ligase complex. CRBN was originally reported as a gene associated with autosomal recessive non-syndromic mild mental retardation. However, the function of CRBN during brain development remains largely unknown. Here we demonstrate that CRBN promotes brain development by facilitating the proliferation of neural stem cells (NSCs). Knockdown of CRBN in zebrafish embryos impaired brain development and led to small brains, as did treatment with thalidomide. By contrast, overexpression of CRBN resulted in enlarged brains, leading to the expansion of NSC regions and increased cell proliferation in the early brain field and an expanded expression of brain region-specific genes and neural and glial marker genes. These results demonstrate that CRBN functions in the determination of brain size by regulating the proliferation of NSCs during development. | |||||
| 書誌情報 |
iScience 巻 15, p. 95-108, 発行日 2019-05 |
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| 出版者 | ||||||
| 出版者 | Cell Press | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2589-0042 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 31055217 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1016/j.isci.2019.04.007 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.sciencedirect.com/science/article/pii/S258900421930104X?via%3Dihub | |||||
