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Primary functional brain connections associated with melancholic major depressive disorder and modulation by antidepressants.
https://repo.qst.go.jp/records/79107
https://repo.qst.go.jp/records/79107249717a2-3fde-4276-9160-7294025af227
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-01-08 | |||||
| タイトル | ||||||
| タイトル | Primary functional brain connections associated with melancholic major depressive disorder and modulation by antidepressants. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Ichikawa, Naho
× Ichikawa, Naho× Lisi, Giuseppe× Yahata, Noriaki× Okada, Go× Takamura, Masahiro× Ryu-Ichiro, Hashimoto× Yamada, Takashi× Yamada, Makiko× Suhara, Tetsuya× Moriguchi, Sho× Mimura, Masaru× Yoshihara, Yujiro× Takahashi, Hidehiko× Kasai, Kiyoto× Kato, Nobumasa× Yamawaki, Shigeto× Seymour, Ben× Kawato, Mitsuo× Morimoto, Jun× Okamoto, Yasumasa× Noriaki, Yahata× Makiko, Yamada× Tetsuya, Suhara× Sho, Moriguchi× Hidehiko, Takahashi |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The limited efficacy of available antidepressant therapies may be due to how they affect the underlying brain network. The purpose of this study was to develop a melancholic MDD biomarker to identify critically important functional connections (FCs), and explore their association to treatments. Resting state fMRI data of 130 individuals (65 melancholic major depressive disorder (MDD) patients, 65 healthy controls) were included to build a melancholic MDD classifier, and 10 FCs were selected by our sparse machine learning algorithm. This biomarker generalized to a drug-free independent cohort of melancholic MDD, and did not generalize to other MDD subtypes or other psychiatric disorders. Moreover, we found that antidepressants had a heterogeneous effect on the identified FCs of 25 melancholic MDDs. In particular, it did impact the FC between left dorsolateral prefrontal cortex (DLPFC)/inferior frontal gyrus (IFG) and posterior cingulate cortex (PCC)/precuneus, ranked as the second 'most important' FC based on the biomarker weights, whilst other eight FCs were normalized. Given that left DLPFC has been proposed as an explicit target of depression treatments, this suggest that the limited efficacy of antidepressants might be compensated by combining therapies with targeted treatment as an optimized approach in the future. | |||||
| 書誌情報 |
Scientific reports 巻 10, 号 1, p. 3542, 発行日 2020-02 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2045-2322 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 32103088 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1038/s41598-020-60527-z | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.nature.com/articles/s41598-020-60527-z | |||||
