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Cooperative interaction among BMAL1, HSF1, and p53 protects mammalian cells from UV stress
https://repo.qst.go.jp/records/79079
https://repo.qst.go.jp/records/79079a76620ea-3399-4875-abb0-463e527b183a
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-02-28 | |||||
| タイトル | ||||||
| タイトル | Cooperative interaction among BMAL1, HSF1, and p53 protects mammalian cells from UV stress | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Kawamura, Genki
× Kawamura, Genki× Hattori, Mitsuru× Takamatsu, Ken× Tsukada, Teruyo× Ninomiya, Yasuharu× Benjamin, Ivor× Paolo, Sassone-Corsi× Ozawa, Takeaki× Tamaru, Teruya× Yasuharu, Ninomiya |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The circadian clock allows physiological systems to adapt to their changing environment by synchronizing their timings in response to external stimuli. Previously, we reported clock- controlled adaptive responses to heat-shock and oxidative stress and showed how the cir- cadian clock interacts with BMAL1 and HSF1. Here, we present a similar clock-controlled adaptation to UV damage. In response to UV irradiation, HSF1 and tumor suppressor p53 regulate the expression of the clock gene Per2 in a time-dependent manner. UV irradiation first activates the HSF1 pathway, which subsequently activates the p53 pathway. Importantly, BMAL1 regulates both HSF1 and p53 through the BMAL1–HSF1 interaction to synchronize the cellular clock. Based on these findings and transcriptome analysis, we propose that the circadian clock protects cells against the UV stress through sequential and hierarchical interactions between the circadian clock, the heat shock response, and a tumor suppressive mechanism. | |||||
| 書誌情報 |
COMMUNICATIONS BIOLOGY 巻 1, p. 204, 発行日 2018-11 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2399-3642 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 30480104 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1038/s42003-018-0209-1 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.nature.com/articles/s42003-018-0209-1 | |||||
