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BNCT dose distribution in tissue slice based on microscopic images of alpha particle tracks from 10B(n, α)7Li reactions
https://repo.qst.go.jp/records/79040
https://repo.qst.go.jp/records/79040d0e11312-e3eb-47e6-9220-9484413b5247
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-01-09 | |||||
| タイトル | ||||||
| タイトル | BNCT dose distribution in tissue slice based on microscopic images of alpha particle tracks from 10B(n, α)7Li reactions | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Ogawara, Ryo
× Ogawara, Ryo× Kusumoto, Tamon× Kodaira, Satoshi× Konishi, Teruaki× Ogawara, Ryo× Kusumoto, Tamon× Kodaira, Satoshi× Konishi, Teruaki |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Boron neutron capture therapy (BNCT) using thermal neutrons and boron delivery agents is a radiation therapy with interesting characteristics being a tumor selectivity at a cellular level. The boron delivery agents are concentrated in tumor cells greater than normal cells, and emit alpha particles and lithium-7 ions by a neutron capture reaction of 10B(n, α)7Li. These particles cause a sufficient damage to only single cells accumulating the boron delivery agents because their path lengths are less than the cell sizes. To evaluate absorbed doses of BNCT, measuring not only an irradiated thermal neutron fluence but also an amount of a boron-10 uptake in cancer cells is required. The most used techniques for evaluating an amount of a boron-10 uptake are inductively coupled plasma mass spectrometry (ICP-MS), positron emission tomography (PET) with 4-borono-2-18F-fluoro-l-phenylalanine, prompt gamma neutron activation analysis (PGNAA) and neutron capture autoradiography (NCAR) with solid-state nuclear track detectors (SSNTD). The NCAR with SSNTD can measured boron-10 uptake distributions in tissues with a superior spatial resolution compared with the other techniques by detecting single tracks of alpha particles from 10B(n, α)7Li reactions. The detailed boron-10 uptake distributions in tissues is an important information for validating effectiveness of combinations of a boron delivery agent and a cancer. CR-39 nuclear track detector is well known as an efficient SSNTD for detecting ionization particles. The track registration sensitivity of CR-39, which is determined by a velocity ratio of bulk etch and track etch, depend on linear energy transfer (LET) and incident angle to CR-39 surface of injected ions. Thus, the CR-39 is useful for evaluating absorbed doses of ionization particles in complex radiation fields containing photon backgrounds (i.e. neutron fields and space radiation environment), because background noises of the low LET photons can be negligible in CR-39. In this work, we evaluated BNCT dose distribution in tissue slices of HSG cell line based on microscopic images of alpha tracks from 10B(n, α)7Li reactions using CR-39. The boron-10 uptake obtained by measurements with CR-39 was similar to results in ICP-MS. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | ABiS Symposium Forefront and Future of Electron Microscopic Imaging | |||||
| 発表年月日 | ||||||
| 日付 | 2020-02-14 | |||||
| 日付タイプ | Issued | |||||
