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A Nucleoside Derivative 5‑Vinyluridine (VrU) for Imaging RNA in Cells and Animals
https://repo.qst.go.jp/records/79025
https://repo.qst.go.jp/records/7902565d19d03-2f15-41ea-92b8-6f3ea5f11010
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-02-20 | |||||
| タイトル | ||||||
| タイトル | A Nucleoside Derivative 5‑Vinyluridine (VrU) for Imaging RNA in Cells and Animals | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Hong-shan, Liu
× Hong-shan, Liu× Ishizuka, Takumi× Kawaguchi, Makiko× Nishii, Ryuichi× Kataoka, Hiroaki× Xu, Yan× Ryuichi, Nishii |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | In the present study, we used a nucleoside derivative 5-vinyluridine (VrU) for labeling during cell division and for tumor imaging in living mice. We demonstrated that the functional nucleoside bearing a 5-vinyl group is metabolically incorporated into cellular RNA and can be used to image RNA using a Diels–Alder reaction. The reagent allows for simultaneous and clear imaging of DNA and RNA in mammalian cells at single-cell resolution. We extended this approach to observe DNA and RNA behaviors in several basic stages of cell division. We further demonstrated that the derivative can be used for fluorescence imaging of tumor in live mice. | |||||
| 書誌情報 |
Bioconjugate Chem 巻 30, 号 11, p. 2958-2966, 発行日 2019-10 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1043-1802 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1021/acs.bioconjchem.9b00643 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://pubs.acs.org/doi/abs/10.1021/acs.bioconjchem.9b00643 | |||||
