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Verification of dose estimation of Auger electrons emitted from Cu-64 using a combination of FNTD measurements and Monte Carlo simulations
https://repo.qst.go.jp/records/78898
https://repo.qst.go.jp/records/788988731feec-7be9-4c40-9a54-c036340e2dd0
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-02-04 | |||||
| タイトル | ||||||
| タイトル | Verification of dose estimation of Auger electrons emitted from Cu-64 using a combination of FNTD measurements and Monte Carlo simulations | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Kusumoto, Tamon
× Kusumoto, Tamon× Matsuya, Y.× Baba, K.× Ogawara, Ryo× Akselrod, M.S.× Harrison, J.× Fomenko, V.× Kai, T.× Ishikawa, M.× Hasegawa, Sumitaka× Kodaira, Satoshi× Tamon, Kusumoto× Ryo, Ogawara× Sumitaka, Hasegawa× Satoshi, Kodaira |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | We report the dose measurement technique for emitted particles from Cu-64 source using a combination of Fluorescent Nuclear Track Detector (FNTD), which is Al2O3 single crystal doped with C and Mg, and Monte Carlo simulations in the PHITS code and Geant4 toolkit. The relatively high fluorescence intensity induced by Auger electrons is observed at the FNTD surface. Then, the fluorescence intensity monotonically reduces as the depth from the surface increases. The results obtained using the PHITS Monte Carlo simulation code is very similar to that of Geant4. Also, the simulations are in good agreement with experimental results. These findings prove that the signal induced by Auger electrons is successfully measured using FNTD. Additionally, the high signal at the FNTD surface implies that Auger electrons can work effectively to kill cancer cells proximal to a Cu-64 source while minimizing damage effects on normal cells distal to the source. At 15 μm depth in the crystal, which is the mean tissue cell radius, the relative dose of beta particles is about 24% of that at the FNTD surface. Therefore, the contribution of free radicals created by beta particles should be accounted for to clarify the impact of Cu-64 on tissues. | |||||
| 書誌情報 |
Radiation Measurements 巻 132, p. 106256, 発行日 2020-03 |
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| 出版者 | ||||||
| 出版者 | Elsevier | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1350-4487 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1016/j.radmeas.2020.106256 | |||||
| 関連サイト | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1016/j.radmeas.2020.106256 | |||||
