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PET/CT for Inflammatory Diseases (Basic Science of PET Imaging for Inflammatory Diseases)
https://repo.qst.go.jp/records/78494
https://repo.qst.go.jp/records/784943d7dca67-6299-4a30-9e43-4fd5117c1827
| Item type | 一般雑誌記事 / Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-01-22 | |||||
| タイトル | ||||||
| タイトル | PET/CT for Inflammatory Diseases (Basic Science of PET Imaging for Inflammatory Diseases) | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Kubota , Kazuo
× Kubota , Kazuo× Mikako, Ogawa× Ji, Bin× Watabe, Tadashi× Ming-Rong, Zhang× Suzuki, Hiromi× Sawada, Makoto× Nishi, Kodai× Kudo, Takashi× Mikako, Ogawa× Ji, Bin× Ming-Rong, Zhang |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | FDG-PET/CT has recently emerged as a useful tool for the evaluation of inflammatory diseases too, in addition to that of malignant diseases. The imaging is based on active glucose utilization by inflammatory tissue. Autoradiography studies have demonstrated high FDG uptake in macrophages, granulocytes, fibroblasts, and granulation tissue. Especially, activated macrophages are responsible for the elevated FDG uptake in some types of inflammation. According to one study, after activation by lipopolysaccharide of cultured macrophages, the [14C]2DG uptake by the cells doubled, reaching the level seen in glioblastoma cells. In activated macrophages, increase in the expression of total GLUT1 and redistributions from the intracellular compartments toward the cell surface have been reported. In one rheumatoid arthritis model, following stimulation by hypoxia or TNF-α, the highest elevation of the [3H]FDG uptake was observed in the fibroblasts, followed by that in macrophages and neutrophils. As the fundamental mechanism of elevated glucose uptake in both cancer cells and inflammatory cells, activation of glucose metabolism as an adaptive response to a hypoxic environment has been reported, with transcription factor HIF-1α playing a key role. Inflammatory cells and cancer cells seem to share the same molecular mechanism of elevated glucose metabolism, lending support to the notion of usefulness of FDGPET/CT for the evaluation of inflammatory diseases, besides cancer. | |||||
| 書誌情報 |
PET/CT for Inflammatory Diseases (Basic Science of PET Imaging for Inflammatory Diseases) 発行日 2019-12 |
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| 出版者 | ||||||
| 出版者 | Springer | |||||
| ISBN | ||||||
| 識別子タイプ | ISBN | |||||
| 関連識別子 | 978-981-15-0809-7 | |||||
| 関連サイト | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1007/978-981-15-0810-3_1 | |||||
