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Ion beams for space radiation radiobiological effect studies
https://repo.qst.go.jp/records/78385
https://repo.qst.go.jp/records/78385fa4647ac-d945-4a6e-827b-0896b8162bbc
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-01-09 | |||||
| タイトル | ||||||
| タイトル | Ion beams for space radiation radiobiological effect studies | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Tsuey Chew, Ming
× Tsuey Chew, Ming× Nisbet, Andrew× Jones, Bleddyn× Suzuki, Masao× Matsufuji, Naruhiro× Murakami, Takeshi× A. Bradley, David× Masao, Suzuki× Naruhiro, Matsufuji× Takeshi, Murakami |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Space radiation exposures to the heavier particles found in galactic cosmic rays (GCR) present a risk in mannedspace travel, particularly to the central nervous system (CNS). GCR are made up of a mixture of multiple chargedparticles such as protons,4He, and56Fe heavy ions. The most harmful to the CNS are the more highly chargedand energetic (HZE) particles, including56Fe because of their significant biological effect contribution to GCRdose and high linear energy transfer. These HZE particles can result in altered cognitive function, reduced motorfunction and behavioural changes and long term chronic brain disease. There is currently a lack of data on thebiological response to56Fe ions. In this regard, ground based experiments could be used to infer the effects of thecosmic environment on cell survival. A mono-energetic beam of56Fe ions was generated by the Heavy IonMedical Accelerator Chiba, National Institute of Radiological Sciences, Chiba, Japan. Three different types ofglioblastoma multiforme (GBM) cell lines were studied. Using GBM cell lines which arise from the glia cells couldaid in the understanding of the effects of space radiation to the brain. Clonogenic assay was used to determinethe efficacy of the radiations. Certain strains of GBM are low-dose hypersensitive and hence, the very low dosesused to study space radiation here are relevant. Results show that 0.2 Gy56Fe (500 MeV/- 200 keV/μm) ionswere able to inactivate approximately 8% of T98G, 15% LN18 and 27% of U87 cells. These results may infer anddemonstrate the deleterious effects of56Fe ions on human CNS, since a significant percentage of GBM cells werekilled at very low doses. The data presented may therefore be employed in assessing risk related to high LETradiation exposure, simulating the effects in space radiation. | |||||
| 書誌情報 |
Radiation Physics and Chemistry 巻 165, p. 108373-1, 発行日 2019-12 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0969-806X | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1016/j.radphyschem.2019.108373 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.sciencedirect.com/science/article/pii/S0969806X19304670 | |||||
