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Though it is desirable to perform sufficient duration of a dynamic PET scan to estimate accurate non-displaceable binding potential (BPND), imaging over 1 hour is impractical for a clinical setting. This study was aimed at optimizing a protocol for a 20-min static emission scan to obtain a reliable target-to-reference ratio of radioligand concentrations in comparison with analytical models with dynamic scan data and an arterial input function.\nMethods \nTen subjects consisting of 5 healthy controls (HCs) and 3 AD and 2 progressive supranuclear palsy (PSP) patients underwent dynamic PET scans over 150 or 180 minutes with a break between 60 and 90 min or 120 min after intravenous injection of [18F]PM-PBB3. Serial arterial blood samples were withdrawn during the scan to determine a metabolite-corrected plasma input function. Regional time-activity curves were analyzed with 1- and 2-tissue compartment models (TCMs) and Logan’s graphical analysis (LGA). Time-stability of total distribution volume (VT) values was examined to estimate scan duration sufficient for robust determination of VT. BPND of [18F]PM-PBB3 was calculated using VT obtained with LGA with the cerebellum as a reference. An averaged target-to-cerebellum ratio in a 20-minute frame beginning at different time points after radioligand injection was calculated as standardized uptake value ratio (SUVR). SUVR-1 values were then compared with BPND to determine an optimal time frame to initiate the static scan.  \nResults\nA peak [18F]PM-PBB3 SUV in the brain approximated 2.5 at \u003c 5 minutes, followed by rapid radioactivity washout. Radioligand retentions in the lateral temporal cortex of AD patients and midbrain of PSP patients were characteristically increased relative to HCs. All radiometabolites in plasma were polar than unmetabolized [18F]PM-PBB3. The parent fraction was decreased gradually to 20% at 60min and 9% at 150 min. 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  1. 学会発表・講演等
  2. ポスター発表

Establishment of a simplified method to quantify [18F]PM-PBB3 ( [18F]APN-1607) binding in the brains of living human subjects

https://repo.qst.go.jp/records/78187
https://repo.qst.go.jp/records/78187
04739f4b-4802-4cf1-aed4-c2ba96c0c3d7
Item type 会議発表用資料 / Presentation(1)
公開日 2019-12-23
タイトル
タイトル Establishment of a simplified method to quantify [18F]PM-PBB3 ( [18F]APN-1607) binding in the brains of living human subjects
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_c94f
資源タイプ conference object
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 関, 千江

× 関, 千江

WEKO 879714

関, 千江

Search repository
Tagai, Kenji

× Tagai, Kenji

WEKO 879715

Tagai, Kenji

Search repository
Shimada, Hitoshi

× Shimada, Hitoshi

WEKO 879716

Shimada, Hitoshi

Search repository
Takahata, Keisuke

× Takahata, Keisuke

WEKO 879717

Takahata, Keisuke

Search repository
Kubota, Manabu

× Kubota, Manabu

WEKO 879718

Kubota, Manabu

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Takado, Yuhei

× Takado, Yuhei

WEKO 879719

Takado, Yuhei

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Shinoto, Hitoshi

× Shinoto, Hitoshi

WEKO 879720

Shinoto, Hitoshi

Search repository
Kimura, Yasuyuki

× Kimura, Yasuyuki

WEKO 879721

Kimura, Yasuyuki

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Ichise, Masanori

× Ichise, Masanori

WEKO 879722

Ichise, Masanori

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Okada, Maki

× Okada, Maki

WEKO 879723

Okada, Maki

Search repository
Kikuchi, Tatsuya

× Kikuchi, Tatsuya

WEKO 879724

Kikuchi, Tatsuya

Search repository
Higuchi, Makoto

× Higuchi, Makoto

WEKO 879725

Higuchi, Makoto

Search repository
Seki, Chie

× Seki, Chie

WEKO 879726

en Seki, Chie

Search repository
Tagai, Kenji

× Tagai, Kenji

WEKO 879727

en Tagai, Kenji

Search repository
Shimada, Hitoshi

× Shimada, Hitoshi

WEKO 879728

en Shimada, Hitoshi

Search repository
Takahata, Keisuke

× Takahata, Keisuke

WEKO 879729

en Takahata, Keisuke

Search repository
Kubota, Manabu

× Kubota, Manabu

WEKO 879730

en Kubota, Manabu

Search repository
Takado, Yuhei

× Takado, Yuhei

WEKO 879731

en Takado, Yuhei

Search repository
Shinoto, Hitoshi

× Shinoto, Hitoshi

WEKO 879732

en Shinoto, Hitoshi

Search repository
Kimura, Yasuyuki

× Kimura, Yasuyuki

WEKO 879733

en Kimura, Yasuyuki

Search repository
Ichise, Masanori

× Ichise, Masanori

WEKO 879734

en Ichise, Masanori

Search repository
Okada, Maki

× Okada, Maki

WEKO 879735

en Okada, Maki

Search repository
Kikuchi, Tatsuya

× Kikuchi, Tatsuya

WEKO 879736

en Kikuchi, Tatsuya

Search repository
Higuchi, Makoto

× Higuchi, Makoto

WEKO 879737

en Higuchi, Makoto

Search repository
抄録
内容記述タイプ Abstract
内容記述 Aim
PET imaging with [18F]PM-PBB3 (a.k.a.[18F]APN-1607*) has demonstrated the capability of this radioligand for high-contrast visualization of tau deposits in the brains of Alzheimer’s disease (AD) and diverse other neurodegenerative disorders. Though it is desirable to perform sufficient duration of a dynamic PET scan to estimate accurate non-displaceable binding potential (BPND), imaging over 1 hour is impractical for a clinical setting. This study was aimed at optimizing a protocol for a 20-min static emission scan to obtain a reliable target-to-reference ratio of radioligand concentrations in comparison with analytical models with dynamic scan data and an arterial input function.
Methods
Ten subjects consisting of 5 healthy controls (HCs) and 3 AD and 2 progressive supranuclear palsy (PSP) patients underwent dynamic PET scans over 150 or 180 minutes with a break between 60 and 90 min or 120 min after intravenous injection of [18F]PM-PBB3. Serial arterial blood samples were withdrawn during the scan to determine a metabolite-corrected plasma input function. Regional time-activity curves were analyzed with 1- and 2-tissue compartment models (TCMs) and Logan’s graphical analysis (LGA). Time-stability of total distribution volume (VT) values was examined to estimate scan duration sufficient for robust determination of VT. BPND of [18F]PM-PBB3 was calculated using VT obtained with LGA with the cerebellum as a reference. An averaged target-to-cerebellum ratio in a 20-minute frame beginning at different time points after radioligand injection was calculated as standardized uptake value ratio (SUVR). SUVR-1 values were then compared with BPND to determine an optimal time frame to initiate the static scan.
Results
A peak [18F]PM-PBB3 SUV in the brain approximated 2.5 at < 5 minutes, followed by rapid radioactivity washout. Radioligand retentions in the lateral temporal cortex of AD patients and midbrain of PSP patients were characteristically increased relative to HCs. All radiometabolites in plasma were polar than unmetabolized [18F]PM-PBB3. The parent fraction was decreased gradually to 20% at 60min and 9% at 150 min. Two-TCM better described the radioligand kinetics in target regions than 1-TCM. VT values obtained with LGA presented the highest time-stability, and SUVR-1 values at 90-110 min showed higher correlation with BPND than any other time frame.
Conclusions
[18F]PM-PBB3 showed reversible binding kinetics, which could be described without radiometabolite compartments in the brain. Estimation of SUVR at 90-110 min can be employed as a simplified means to quantify the radioligand retention with sufficient robustness.
会議概要(会議名, 開催地, 会期, 主催者等)
内容記述タイプ Other
内容記述 Brain & Brain PET 2019に参加および発表
発表年月日
日付 2019-07-06
日付タイプ Issued
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