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Experimental quantification of internally generated thermal neutron fluence in heavy ion therapy
https://repo.qst.go.jp/records/78078
https://repo.qst.go.jp/records/780782153bed6-a1e0-4f39-ae1a-96c6f6e40e37
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2019-10-16 | |||||
| タイトル | ||||||
| タイトル | Experimental quantification of internally generated thermal neutron fluence in heavy ion therapy | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Chacon, Andrew
× Chacon, Andrew× Mohammadi, Akram× Howell, N.× Middleton, R.× Fraser, B.× N. Wyatt× Harley Rutherford× R. Franklin, D.× Takyu, Sodai× Nishikido, Fumihiko× Hirayama, Ryoichi× Yamaya, Taiga× Matsufuji, Naruhiro× Rosenfeld, A.× Guatelli, S.× Safavi naeini, Mitra× Chacon, Andrew× Mohammadi, Akram× Rutherford, Harley× Takyu, Sodai× Nishikido, Fumihiko× Hirayama, Ryoichi× Yamaya, Taiga× Matsufuji, Naruhiro× Safavi naeini, Mitra |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | During heavy ion therapy, some particles in the beam undergo atomic nuclear inelastic collisions with other nuclei in the target, resulting in the production of a range of nuclear fragments, including neutrons. The neutron component is moderated by matter in the target, causing them to lose energy and thermalise. These neutrons are of particular interest as they offer the potential for therapeutic applications via neutron capture. Accurate and reliable quantification of the thermal neutron fluence produced during particle therapy will provide valuable information regarding the feasibility of therapeutic exploitation of this thermal neutron field. However, measurement of thermal neutron fluence is extremely challenging due to the intense and diverse mixed radiation field in the target volume. In this work, we present the results of experimental quantification of thermal neutron fluence, performed using the gold activation method, during carbon and helium beam therapy. Geant4 Monte Carlo simulations were used to validate the approach, establishing that the activation of gold is almost exclusively due to neutron capture, and that nearly all gamma photons detected in the vicinity of 411 keV result from the decay of the activated gold. The method was then applied to experimentally measure the fluence of thermal neutrons per Gy(RBE) of delivered dose during carbon and helium beam therapy, both inside and outside of the beam in a poly(methyl methacrylate) (PMMA) phantom. Thermal neutron fluence was measured at four different depths: at the entrance, distal edge, middle of the SOBP and in the tail region of the spread-out Bragg peak (SOBP). o our knowledge, this is the first time that this method has been used in particle therapy. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | The 2019 IEEE Nuclear Science Symposium (NSS) and Medical Imaging Conference (MIC) | |||||
| 発表年月日 | ||||||
| 日付 | 2019-10-31 | |||||
| 日付タイプ | Issued | |||||
