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Evaluation of ionizing radiation induced early DNA damage on a cell nucleus by integrated track structure Monte Carlo simulations using Geant4-DNA
https://repo.qst.go.jp/records/77927
https://repo.qst.go.jp/records/7792740040f60-bc8a-4ff4-8cc0-9123142884cf
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2019-12-11 | |||||
| タイトル | ||||||
| タイトル | Evaluation of ionizing radiation induced early DNA damage on a cell nucleus by integrated track structure Monte Carlo simulations using Geant4-DNA | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Sakata, Dousatsu
× Sakata, Dousatsu× Sakata, Dousatsu |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Purpose: Monte Carlo (MC) mechanistic simulations are a promising tool for the modelling of early DNA damage induction by ionizing radiation. They indeed provide functionalities which allow to simulate not only physical interactions but also chemical processes in combination with simplified geometries of biological targets for the prediction of such damage. In the last decades, several MC codes were developed to predict DNA damage, like KURBUC, PARTRAC and Geant4-DNA. Recently, Geant4-DNA has demonstrated the possibility to evaluate early DNA damage in an E. coli bacterium and in a fibroblast cell nucleus irradiated by protons. We have presented for the first time the combination of such features (physics, chemistry and biological geometry) in a single Geant4-DNA application for the modelling of early DNA damage induction in a cell nucleus. In this talk, we present progress of the modelling in Geant4-DNA of biological DNA damage. Material and Methods: As used in the previous work, we built fractal base cell nucleus geometry composed by double-helix DNA fibre and histone. We simulated physical particle transportation followed by radiolysis chemical product productions, diffusion of free radicals/ions and chemical reactions in gamma and proton radiation fields. Early DNA damage is calculated as either direct damage or indirect damage. Then the damage clusters are classified according to the damage type definition proposed by Nikjoo, to the purpose for calculation of damage complexity used in biological repair prediction. Results: In this talk, mainly DSB yields and fraction of indirect damage and biological repair will be presented. For instance, Figure 1 shows the scaled yield of γH2AX till 24 hours after from gamma irradiation from a 60Co radiation source. The simulated repair prediction shows a good agreement with experimental data. Conclusion: We have developed for the first time a Monte Carlo simulation based on Geant4-DNA that calculates not only early DNA damage but also late DNA damage prediction such as foci accumulation like γH2AX. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Geant4 school & monte carlo workshop for radiotherapy, imaging and radiation protection | |||||
| 発表年月日 | ||||||
| 日付 | 2019-12-06 | |||||
| 日付タイプ | Issued | |||||
