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Free Energy Profile for Unwrapping Outer Superhelical Turn of CENP-A Nucleosome
https://repo.qst.go.jp/records/77859
https://repo.qst.go.jp/records/77859ad31b73e-34e3-4821-8cf0-c270ae3cac04
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2019-07-01 | |||||
| タイトル | ||||||
| タイトル | Free Energy Profile for Unwrapping Outer Superhelical Turn of CENP-A Nucleosome | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Kono, Hidetoshi
× Kono, Hidetoshi× Sakuraba, Shun× Ishida, Hisashi× Hidetoshi, Kono× Shun, Sakuraba× Hisashi, Ishida |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Eukaryotic genome is packaged in a nucleus in the form of chromatin. The fundamental structural unit of the chromatin is the protein-DNA complex, nucleosome, where DNA of about 150 bp is wrapped around a histone core almost twice. In cellular processes such as gene expression, DNA repair and duplication, the nucleosomal DNA has to be unwrapped. Histone proteins have their variants, indicating there are a variety of constitutions of nucleosomes. These different constitutions are observed in different cellular processes. To investigate differences among nucleosomes, we calculated free energy profiles for unwrapping the outer superhelical turn of CENP-A nucleosome and compared them with those of the canonical nucleosome. The free energy profiles for CENP-A nucleosome suggest that CENP-A nucleosome is most stable when 16 to 22 bps are unwrapped in total whereas the canonical nucleosome is most stable when it is fully wrapped. This indicates that the flexible conformation of CENP-A nucleosome is ready to provide binding sites for the structural integrity of the centromere. | |||||
| 書誌情報 |
Biophysics and Physicobiology 巻 16, p. 337-343, 発行日 2019-12 |
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| 出版者 | ||||||
| 出版者 | The Biophysical Society of Japan | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2189-4779 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.2142/biophysico.16.0_337 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.jstage.jst.go.jp/article/biophysico/16/0/16_337/_article/-char/en | |||||
