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Advanced microbeam irradiation system for single cell analysis of defensive cellular response against radiation
https://repo.qst.go.jp/records/77813
https://repo.qst.go.jp/records/7781376341c98-fdd3-48e8-b409-ab18c0c0fe5b
| Item type | 一般雑誌記事 / Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2019-12-06 | |||||
| タイトル | ||||||
| タイトル | Advanced microbeam irradiation system for single cell analysis of defensive cellular response against radiation | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Konishi, Teruaki
× Konishi, Teruaki× Ohsawa, Daisuke× Kobayashi, Alisa× Oikawa, Masakazu× Konishi, Teruaki× Ohsawa, Daisuke× Kobayashi, Alisa× Oikawa, Masakazu |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Advanced microbeam irradiation system made possible to deliver a defined amount of radiation on a single cell with a few micrometer resolution. Our microbeam, the Single-Particle Irradiation system to CEll (SPICE) provides a 3.4 MeV proton microbeam focused with a quadrupole magnetic lens on an upward vertical beam line (1,2). SPICE is the only proton microbeam in Japan that can target nucleus, cytoplasm, or both with high throughput, high targeting accuracy along with promising stability. In this presentation, the state of the art features of SPICE will be introduced along with our recent results from single cell analysis of microbeam targeted cells on defensive signalling through intra- and inter-cellular response against radiation, such as cytoplasmic damage response (3,4), and cell-to-cell communication between human normal and carcinoma cells (5-7). 1. T. Konishi, et al., J Radiat Res 54(2013) 736-747. 2. D. Ohsawa, et al., Nucl Instrum Methods Phys. Res B 453 (2019) 9-14. 3. J. Wang and T. Konishi, Cancer Sci, 110 (2019) 686-696. 4. T. Konishi, et al., J. Radiat Cancer Res 9 (2018)183-189. 5. A. Kobayashi, et al., Radiat Prot Dosim 183 (2019) 142-146. 6. N. Autsavapromporn, et al., Radiat Res 191 (2019) 211-216. 7. A. Kobayashi, et al., Mutat Res-Fund Mol M 803-805 (2017) 1-8. |
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| 書誌情報 |
Microscopy 巻 46, 号 Issue Supplement_1, p. i48, 発行日 2019-12 |
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| 出版者 | ||||||
| 出版者 | Oxford University Press | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2050-5698 | |||||
| 関連サイト | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1093/jmicro/dfz075 | |||||
