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Diallyl Disulfide Mitigates DNA Damage and Spleen Tissue Effects After Irradiation
https://repo.qst.go.jp/records/77661
https://repo.qst.go.jp/records/7766188609c77-0334-4eb0-bddd-4e550b17a280
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2019-11-27 | |||||
| タイトル | ||||||
| タイトル | Diallyl Disulfide Mitigates DNA Damage and Spleen Tissue Effects After Irradiation | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Nakajima, Tetsuo
× Nakajima, Tetsuo× Vares, Guillaume× Ninomiya, Yasuharu× Wang, Bing× Katsube, Takanori× Tanaka, Kaoru× Maruyama, Kouichi× Nenoi, Mitsuru× Tetsuo, Nakajima× Vares, Guillaume× Yasuharu, Ninomiya× Bing, Wang× Takanori, Katsube× Kaoru, Tanaka× Kouichi, Maruyama× Mitsuru, Nenoi |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background: Several factors found in foods are beneficial to human health and they may contribute to radiation protection. Taking food factors could be an easy way to reduce the effects of radiation after nuclear accidents, as well as secondary radiation risks after cancer radiotherapy or space missions. Here, diallyl disulfide (DADS), a component of garlic oil, was studied for its ability to mitigate radiation damage. Material/Methods: We investigated the effects of DADS on micronucleus (MN) formation and apoptosis in HepG2 cells by use of 4-Gy X-ray irradiation. We also assessed the effects of DADS on radiation damage in vivo by evaluating MN formation in bone marrow cells in mice (BALB/c, 8-week-old females) after oral intake of DADS prior to irradiation with 4 Gy. Several tissue effects were also investigated. Results: The presence of DADS inhibited MN formation, whereas DADS had no influence on the radiation-induced inhibition of cell cycle progression in HepG2 cells. An increase in apoptosis in HepG2 cells was induced after irradiation, and this effect was stronger in the presence of DADS than in its absence. In mice, when DADS was administered daily for 3 days prior to irradiation, MN formation in irradiated mice was decreased. The decrease in MN formation in mice was greater with 0.5% DADS compared to 1% DADS. Moreover, an increase in spleen weight observed 3 weeks after irradiation was suppressed in mice administered DADS. Conclusions: DADS is a potential radiation-protective agent that effectively mitigates DNA damage, and its effects in the spleen observed after irradiation may be related to inflammation and carcinogenesis | |||||
| 書誌情報 |
Medical Science Monitor 巻 25, p. 8920-8927, 発行日 2019-11 |
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| 出版者 | ||||||
| 出版者 | International Scientific Information, Inc. | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1643-3750 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 31760404 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.12659/MSM.917207 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.medscimonit.com/download/index/idArt/917207 | |||||
