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Assesment of F-FDG PET/CT texture analysis to discriminate NSCLC from radiation pneumonitis after CIRT
https://repo.qst.go.jp/records/77529
https://repo.qst.go.jp/records/7752916f95ff6-9f14-4984-84cb-94d6289e989a
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2019-11-21 | |||||
| タイトル | ||||||
| タイトル | Assesment of F-FDG PET/CT texture analysis to discriminate NSCLC from radiation pneumonitis after CIRT | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Suga, Makito
× Suga, Makito× Nishii, Ryuichi× Yamazaki, Kana× Kamitaka, Yuto× Miwa, Kenta× Kohno, Ryosuke× Tanimoto, Katsuyuki× Higashi, Tatsuya× Tsuji, Hiroshi× Suga, Makito× Nishii, Ryuichi× Yamazaki, Kana× Kamitaka, Yuto× Miwa, Kenta× Kohno, Ryosuke× Tanimoto, Katsuyuki× Higashi, Tatsuya× Tsuji, Hiroshi |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Aim: The differentiation of local recurrence from a primary tumor and radiation pneumonitis (RP) is critically important for selecting optimal clinical therapeutic strategies to manage post carbon-ion radiotherapy (CIRT) in patients with non-small cell lung cancer (NSCLC). Although 18F-FDG PET/CT (FDG-PET/CT) plays a key role in the metabolic imaging of patients with NSCLC who require CIRT management, PET/CT diagnosis based on SUVmax cannot always distinguish between NSCLC and RP. The present study aimed to determine whether FDG-PET/CT texture parameters can differentiate NSCLC from RP after CIRT. Material and Methods: We retrospectively analyzed FDG-PET/CT image data from 32 patients with histopathologically proven NSCLC who were scheduled to undergo CIRT, and 31 patients who were diagnosed with RP after CIRT (50.0 Gy in 4 fractions/day). Radiation pneumonitis was diagnosed by biopsy or at clinical follow-up > 1 year after CIRT. Volumes of interest (VOI) on tumors were delineated using a threshold of 40% of the maximum standard uptake value (SUVmax) in each lesion. The SUV parameters of SUVmax, SUVpeak, SUVmean, metabolic tumor volume (MTV), total lesion glycolysis (TLG) and seven typical texture parameters of FDG-PET/CT were determined using PETSTAT image-analysis software. Data were statistically compared between NSCLC and RP using nonparametric Wilcoxon rank sum tests. Diagnostic accuracy was assessed using ROC curves. Results: Among SUV parameters, MTV (p < 0.0001) and TLG (p = 0.001) significantly differed between NSCLC and RP. The feature quantities of texture parameters, namely, GLRLM, GLSZM, NGLCM3D, NGLCM and NGTDM significantly differed between NSCLC and RP. The areas under the receiver operating characteristics (ROC) curves (AUC) were as follows: SUVmax 0.64, MTV 0.86, TLG 0.75, GLRLM 0.83, GLSZM 0.76, NGLCM3D 0.71, NGLCM 0.72 and GTDM 0.82. Diagnostic accuracy was better using GLRLRM or NGTDM than SUVmax (p < 0.01). Conclusion: The texture parameters of FDG-PET/CT were useful to differentiate NSCLC from radiation pneumonitis after CIRT, and GLRLM and NGTDM in particular would be promising parameters with excellent diagnostic accuracy. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | EANM2019(ヨーロッパ核医学会) | |||||
| 発表年月日 | ||||||
| 日付 | 2019-10-14 | |||||
| 日付タイプ | Issued | |||||
