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Characterization of Radioadaptive Response in a Mouse Model (Yonezawa Effect)
https://repo.qst.go.jp/records/77448
https://repo.qst.go.jp/records/774487715c068-1696-496b-a5be-ba573bb32d6d
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2019-06-25 | |||||
| タイトル | ||||||
| タイトル | Characterization of Radioadaptive Response in a Mouse Model (Yonezawa Effect) | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Wang, Bing
× Wang, Bing× Liu, Cuihua× Tanaka, Kaoru× Katsube, Takanori× Hirakawa, Hirokazu× Ninomiya, Yasuharu× Maruyama, Kouichi× Murakami, Masahiro× Fujita, Kazuko× Liu, Qiang× Fujimori, Akira× Nenoi, Mitsuru× Wang, Bing× Liu, Cuihua× Tanaka, Kaoru× Katsube, Takanori× Hirakawa, Hirokazu× Ninomiya, Yasuharu× Maruyama, Kouichi× Murakami, Masahiro× Fujita, Kazuko× Fujimori, Akira× Nenoi, Mitsuru |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background: Existence of radioadaptive response (RAR) was reported in varied biosystems. RAR is capable of reducing genotoxicity, cell transformation, mutation and carcinogenesis but the underlying mechanisms remain fragmented. The first RAR mouse model called “Yonezawa Effect” was established by Yonezawa and colleagues using low LET X-rays as both the priming and the challenge doses, and rescue of bone marrow death as the endpoint. Aim: Characterization of RAR in this mouse model. Methods/Results: In a series of investigations, we further demonstrated that 1) existence of RAR using different types of ionizing radiation (IR) including high LET heavy ions; increase in the hematopoietic stem cells/hematopoietic progenitor cells (HSCs/HPCs) measured as endogenous colony forming units-spleen (CFU-S) under RAR; and reduction of delayed homologous recombination (HR) in the nucleated cells in hematopoietic tissues (bone marrow and spleen) using the Rosa26 Direct Repeat-GFP homozygote mice. Conclusions/Discussions: These findings suggest that RAR in mice induced by different types of IR would share a common underlying mechanism: the priming IR-induced resistance in the blood forming tissues, leading to a protective effect on the HSCs/HPCs and rescuing the animals from bone marrow death. On the other hand, reduction of delayed HR may be at least a part of the mechanisms underlying decreased carcinogenesis by RAR. These findings provide a new insight into the mechanistic study on RAR in vivo and suggest that application of RAR would contribute to a more rigorous and scientifically-grounded system of radiation protection in radiotherapy. キーワード：Adaptive response, ionizing radiation, colony forming unites-spleen, homologous recombination, mice |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | The 16th International Congress of Radiation Research (ICRR2019） | |||||
| 発表年月日 | ||||||
| 日付 | 2019-08-26 | |||||
| 日付タイプ | Issued | |||||
