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  1. 原著論文

Assessment of risk factors associated with development of oronasal fistula as a late complication after carbon-ion radiotherapy for head and neck cancer

https://repo.qst.go.jp/records/77446
https://repo.qst.go.jp/records/77446
6bd2f0e3-440a-477f-bef9-00e5c73a16a1
Item type 学術雑誌論文 / Journal Article(1)
公開日 2019-11-14
タイトル
タイトル Assessment of risk factors associated with development of oronasal fistula as a late complication after carbon-ion radiotherapy for head and neck cancer
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 Bhattacharyya, Tapesh

× Bhattacharyya, Tapesh

WEKO 805491

Bhattacharyya, Tapesh

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Koto, Masashi

× Koto, Masashi

WEKO 805492

Koto, Masashi

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Ikawa, Hiroaki

× Ikawa, Hiroaki

WEKO 805493

Ikawa, Hiroaki

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Hayashi, Kazuhiko

× Hayashi, Kazuhiko

WEKO 805494

Hayashi, Kazuhiko

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Hagiwara, Yasuhito

× Hagiwara, Yasuhito

WEKO 805495

Hagiwara, Yasuhito

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Tsuji, Hiroshi

× Tsuji, Hiroshi

WEKO 805496

Tsuji, Hiroshi

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Bhattacharyya, Tapesh

× Bhattacharyya, Tapesh

WEKO 805497

en Bhattacharyya, Tapesh

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Koto, Masashi

× Koto, Masashi

WEKO 805498

en Koto, Masashi

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Ikawa, Hiroaki

× Ikawa, Hiroaki

WEKO 805499

en Ikawa, Hiroaki

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Hayashi, Kazuhiko

× Hayashi, Kazuhiko

WEKO 805500

en Hayashi, Kazuhiko

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Hagiwara, Yasuhito

× Hagiwara, Yasuhito

WEKO 805501

en Hagiwara, Yasuhito

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Tsuji, Hiroshi

× Tsuji, Hiroshi

WEKO 805502

en Tsuji, Hiroshi

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抄録
内容記述タイプ Abstract
内容記述 Background: Oronasal fistulae (ONF) are one of the rare but serious complications of conventional photon radiotherapy. This study aimed to identify the risk factors for the development of ONF after carbon-ion radiotherapy (C-ion RT).
Materials and Methods: The data of 62 cases of sinonasal and oral cavity cancers treated with C-ion RT and followed-up in excess of 5 years were retrospectively reviewed. The correlation between the clinical and dosimetric parameters and the development of ONF was analysed.
Results: A total of 80.6% cases had sinonasal malignancies, and most tumours had advanced T stages (96.8%). Maxillary invasion was observed in 16 cases (25.8%), and malignant melanoma was the most common histology (46.8 %). All the cases received a dose of between 57.6 Gy (RBE) and 64 Gy (RBE) in 16 fractions over 4 weeks. At a median follow up of 88.8 months, 23 cases (37.1%) developed small loca-lised ONF; however, none were of grade III severity. On separate multivariate analyses of clinical param-eters in the entire cohort and in cases without maxillary invasion, the number of teeth irradiated with more than 50 Gy (RBE) was found to be the common significant independent risk factor for development of ONF.
Conclusion: The number of teeth irradiated with more than 50 Gy (RBE) is a significant independent risk factor for the development of ONF, which is a late complication of C-ion RT delivered in 16 fractions.
書誌情報 Radiotherapy and Oncology

巻 144, p. 53-58, 発行日 2019-11
出版者
出版者 ELSEVIER
ISSN
収録物識別子タイプ ISSN
収録物識別子 0167-8140
DOI
識別子タイプ DOI
関連識別子 10.1016/j.radonc.2019.10.015
関連サイト
識別子タイプ URI
関連識別子 https://www.sciencedirect.com/science/article/pii/S0167814019334516
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