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[211At]MABG の薄層クロマトグラフィー手順の探索
https://repo.qst.go.jp/records/77445
https://repo.qst.go.jp/records/7744541fcfaed-4b38-4c2f-96d3-a77170a4bd6b
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2019-11-15 | |||||
| タイトル | ||||||
| タイトル | [211At]MABG の薄層クロマトグラフィー手順の探索 | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
粟生木, 美穂
× 粟生木, 美穂× 西嶋, 剣一× 鷲山, 幸信× 城寶, 大輝× 下山, 彩希× 右近, 直之× 趙, 松吉× 鷲野, 弘明× 高橋, 和弘× 伊藤, 浩× 東, 達也× Aoki, Miho× Nishijima, Kenichi× Koushin, Washiyama× Ukon, Naoyuki× Zhao, Songji× Washino, Komei× Ito, Hiroshi× Higashi, Tatsuya |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Objective: [211At]MABG has been expected to be used in place of [131I]MIBG. When radioactivity of sample is low, such as in metabolite analysis, TLC is attractive. We searched for TLC procedure of [211At]MABG. Methods: [211At]MABG and [125I]MIBG were obtained according to our previous report and were analyzed on HPLC. [211At]MABG, [125I]MIBG, 211At and 125I were evaluated by silica gel TLC, RP-18 modified TLC (RP-TLC) or ITLC. Results: [211At]MABG and [125I]MIBG showed high radiochemical purity (RCP) on HPLC (＞95%). In the case of [125I]MIBG, RCP by TLC and HPLC were similar. However, RCP of [211At]MABG on TLC with EtOH:AcOH (95:5) was low (25%). RP-TLC with MeCN:H2O:TFA (40:60:0.1) or ITLC with 0.9% NaCl were comparable to HPLC, but 211At and [211At]MABG were overlapped. TLC using propanol:10% NH3(aq) (3:1) allowed separation of 211At and [211At]MABG, and was consistent with HPLC. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第59回日本核医学会学術総会 | |||||
| 発表年月日 | ||||||
| 日付 | 2019-11-02 | |||||
| 日付タイプ | Issued | |||||
