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Homologous Recombination Repair Mechanism in Clustered DNA Damage (18J430-FY2018)
https://repo.qst.go.jp/records/77430
https://repo.qst.go.jp/records/7743058688b2a-36a0-4402-bd19-a0a14ee7057e
| Item type | 一般雑誌記事 / Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2019-11-13 | |||||
| タイトル | ||||||
| タイトル | Homologous Recombination Repair Mechanism in Clustered DNA Damage (18J430-FY2018) | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Su, Fengtao
× Su, Fengtao× Chen, Qianqian× Dong, Lu× Konishi, Teruaki× Konishi, Teruaki |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Compared with low let induced simple DSBs, high LET carbon beams induced cluster DSBs include different type of DNA damage: DSBs, SSBs, cross-link, base damage, etc. In our previous data, we confirmed HR Pathway was More Relevant in response Carbon ions induced cluster DNA damage. Different types of repair pathway had important roles in cluster DNA damage in S phase cells. In this project we want to investigate how homologous recombination repair pathway works in clustered DNA damage utilizing HIMAC heavy ion accelerator terminal: 1) In cluster DNA damage, following DSBs end resection, whether other types of DNA damage are also modified or even cut. What kinds of enzyme play this role; 2) Through modified Idu-ChIP assay, we will screen what kind of repair factors play central role in this process; 3) Through multi-fluorescence DNA fiber assay, we will assess how these factors regulate DNA replication progress.This project will characterize unique detail in cluster DNA damage repair mechanism, which is separate with simple DSBs. This will support the basic theory for modifying and developing potential technique in heavy radiotherapy. | |||||
| 書誌情報 |
2018年度放射線医学総合研究所重粒子線がん治療装置等共同利用研究報告書 p. 126, 発行日 2019-09 |
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| 出版者 | ||||||
| 出版者 | 放射線医学総合研究所 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://id.nii.ac.jp/1657/00077313/ | |||||
