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Imaging of 99mTc-DMSA and 18F-FDG in Humans Using a Si/CdTe Compton Camera
https://repo.qst.go.jp/records/77069
https://repo.qst.go.jp/records/770693b37c64d-c8e1-4a71-bf38-8e36a0c7994c
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2019-06-25 | |||||
| タイトル | ||||||
| タイトル | Imaging of 99mTc-DMSA and 18F-FDG in Humans Using a Si/CdTe Compton Camera | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Nakano, Takashi
× Nakano, Takashi× Makoto, Sakai (Gunma Univ.)× Kota, Torikai (Gunma Univ.)× Yoshiyuki, Suzuki (Gunma Univ.)× Shin-ei, Noda (Saitama Medical Univ.)× Yamaguchi, Mitsutaka× Shin'ichiro, Takeda (OIST)× Nagao, Yuuto× Mikiko, Kikuchi (Gunma Univ.)× Hirokazu, Odaka (JAXA)× Tomihiro, Kamiya (Gunma Univ.)× Kawachi, Naoki× Shin, Watanabe (JAXA)× Kazuo, Arakawa (Gunma Univ.)× Tadayuki, Takahashi (JAXA)× Takashi, Nakano× Mitsutaka, Yamaguchi× Yuuto, Nagao× Naoki, Kawachi |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The Compton camera can simultaneously acquire images of multiple isotopes injected in a body; therefore, it has the potential to introduce a new subfield in the field of biomedical imaging applications. The objective of this study is to assess the ability of a prototype semiconductor-based silicon/cadmium telluride (Si/CdTe) Compton camera to simultaneously image the distributions of technetium (99mTc)-dimercaptosuccinic acid (DMSA) (141 keV emission) and 18F-fluorodeoxyglucose (FDG) (511 keV emission) injected into a human volunteer. 99mTc-DMSA and 18F-FDG were injected intravenously into a 25-year-old male volunteer. The distributions of 99mTc-DMSA and 18F-FDG were simultaneously made visible by setting a specified energy window for each radioisotope. The images of these radiopharmaceuticals acquired using the prototype Compton camera were superimposed onto computed tomography images for reference. The reconstructed image showed that 99mTc-DMSA had accumulated in both kidneys, which is consistent with the well-known diagnostic distribution determined by clinical imaging via single-photon emission computed tomography. In the 18F-FDG image, there is broad distribution around the liver and kidneys, which was expected based on routine clinical positron emission tomography imaging. The current study demonstrated for the first time that the Si/CdTe Compton camera was capable of simultaneously imaging the distributions of two radiopharmaceuticals, 99mTc-DMSA and 18F-FDG, in a human body. These results suggest that the Si/CdTe Compton camera has the potential to become a novel modality for nuclear medical diagnoses enabling multi-probe simultaneous tracking. | |||||
| 書誌情報 |
Physics in Medicine & Biology 巻 65, 号 5, p. 05LT01, 発行日 2019-07 |
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| 出版者 | ||||||
| 出版者 | IOP Publishing | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0031-9155 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1088/1361-6560/ab33d8 | |||||
| 関連サイト | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1088/1361-6560/ab33d8 | |||||
