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In vivo rendezvous of small nucleic acid drugs with charge-matched block catiomers to target cancers.
https://repo.qst.go.jp/records/77026
https://repo.qst.go.jp/records/7702614324604-1167-4f94-ba35-65a370a9f265
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2019-10-02 | |||||
| タイトル | ||||||
| タイトル | In vivo rendezvous of small nucleic acid drugs with charge-matched block catiomers to target cancers. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Watanabe, Sumiyo
× Watanabe, Sumiyo× Hayashi, Kotaro× Toh, Kazuko× Jin Kim, Hyun× Liu, Xueying× Chaya, Hiroyuki× Fukushima, Shigeto× Katsushima, Keisuke× Kondo, Yutaka× Uchida, Satoshi× Ogura, Satomi× Nomoto, Takahiro× Takemoto, Hiroyasu× Cabral, Horacio× Kinoh, Hiroaki× Y Tanaka, Hiroyoshi× R Kano, Mitsunobu× Matsumoto, Yu× Fukuhara, Hiroshi× Uchida, Shunya× Nangaku, Masaomi× Osada, Kensuke× Nishiyama, Nobuhiro× Miyata, Kanjiro× Kataoka, Kazunori× Kensuke, Osada |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Stabilisation of fragile oligonucleotides, typically small interfering RNA (siRNA), is one of the most critical issues for oligonucleotide therapeutics. Many previous studies encapsulated oligonucleotides into ~100-nm nanoparticles. However, such nanoparticles inevitably accumulate in liver and spleen. Further, some intractable cancers, e.g., tumours in pancreas and brain, have inherent barrier characteristics preventing the penetration of such nanoparticles into tumour microenvironments. Herein, we report an alternative approach to cancer-targeted oligonucleotide delivery using a Y-shaped block catiomer (YBC) with precisely regulated chain length. Notably, the number of positive charges in YBC is adjusted to match that of negative charges in each oligonucleotide strand (i.e., 20). The YBC rendezvouses with a single oligonucleotide in the bloodstream to generate a dynamic ion-pair, termed unit polyion complex (uPIC). Owing to both significant longevity in the bloodstream and appreciably small size (~18 nm), the uPIC efficiently delivers oligonucleotides into pancreatic tumour and brain tumour models, exerting significant antitumour activity. | |||||
| 書誌情報 |
Nature communications 巻 10, 号 1, p. 1894, 発行日 2019-04 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2041-1723 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 31019193 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1038/s41467-019-09856-w | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.nature.com/articles/s41467-019-09856-w | |||||
