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Reconstruction of physical and biological dose distributions of carbon-ion beam through deconvolution of longitudinal responses
https://repo.qst.go.jp/records/76924
https://repo.qst.go.jp/records/7692479a1ce17-37be-4e2f-9249-68fd6f172629
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2019-09-25 | |||||
| タイトル | ||||||
| タイトル | Reconstruction of physical and biological dose distributions of carbon-ion beam through deconvolution of longitudinal responses | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Kanematsu, Nobuyuki
× Kanematsu, Nobuyuki× Inaniwa, Taku× Yonai, Shunsuke× Mizuno, Hideyuki× Kanematsu, Nobuyuki× Inaniwa, Taku× Yonai, Shunsuke× Mizuno, Hideyuki |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Purpose: This is a theoretical simulation study for proof of concept of radiochromic film dosimetry to measure physical and biological doses without plan‐based quenching correction for patient‐specific quality assurance of carbon‐ion radiotherapy. Methods: We took a layer‐stacking carbon‐ion beam comprised of range‐shifted beamlets. The dosimeter response was simulated according to an experimental quenching model. The beam model followed a treatment planning system. The beam was decomposed into finely arranged beamlets with weights estimated by deconvolution of longitudinal dosimeter responses. The distributions of physical and biological doses were reconstructed from the estimated weights and were compared with the plan. We also evaluated the sensitivity to measurement errors and to erratic delivery with an undelivered beamlet. Results: The reconstructed physical and biological doses accurately reproduced the simulated delivery with errors approximately corresponding to the measurement errors. The erratic beam delivery was easily detectable by comparison of biological dose distribution to the plan. Conclusions: We have developed a method to measure physical and biological doses by longitudinal dosimetry of quenched response without using plan data. The method only involves a general optimization algorithm, a radiobiology model, and experimental beamlet data, and requires no extra corrections. Theoretically, this approach is applicable to various dosimeters and to proton and ion beams of any delivery method, regardless of quenching or biological effectiveness. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第118回日本医学物理学会学術大会 | |||||
| 発表年月日 | ||||||
| 日付 | 2019-09-12 | |||||
| 日付タイプ | Issued | |||||
