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Effects of chronic restraint-induced stress and Fe-particle irradiation on induction of chromosomal aberrations in Trp53-heterozygous mice
https://repo.qst.go.jp/records/76715
https://repo.qst.go.jp/records/767154563f065-5294-418b-aa65-5cd40e0e0371
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2019-09-10 | |||||
| タイトル | ||||||
| タイトル | Effects of chronic restraint-induced stress and Fe-particle irradiation on induction of chromosomal aberrations in Trp53-heterozygous mice | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
勝部, 孝則
× 勝部, 孝則× Wang, Bing× Tanaka, Kaoru× Ninomiya, Yasuharu× Hirakawa, Hirokazu× Liu, Cuihua× Maruyama, Kouichi× Vares, Guillaume× Liu, Qiang× Nakajima, Tetsuo× Fujimori, Akira× Nenoi, Mitsuru× Katsube, Takanori× Wang, Bing× Tanaka, Kaoru× Ninomiya, Yasuharu× Hirakawa, Hirokazu× Liu, Cuihua× Maruyama, Kouichi× Vares, Guillaume× Nakajima, Tetsuo× Fujimori, Akira× Nenoi, Mitsuru |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background: Astronauts develop psychological stress (PS) during space flight because of enclosed environment, zero gravity and altered light-dark cycles. At the same time, they are exposed to cosmic rays including high atomic number and energy (HZE) particles such as iron-56 (Fe) ions. A pioneering study showed that chronic restraint-induced PS (CRIPS) could attenuate Trp53 functions and increase carcinogenesis induced by low linear energy transfer (LET) gamma-rays in Trp53-heterozygous (Trp53+/-) mice. Methods: To elucidate possible modification effects from CRIPS on high LET HZE particles-induced health consequences, Trp53+/- C57BL/6N male mice (six-week-old) were restrained 6 hours per day for consecutive 28 days, and total-body irradiation (TBI) of Fe ions at a dose of 0.1 or 2 Gy was given on the 8th day. Chromosomal aberrations (CAs) in splenocytes were observed by fluorescence in situ hybridization (FISH) at the end of the 28-day restraint regimen. Results/Conclusions: Induction of PS in our experimental model was confirmed by an increase in urinary corticosterone level. CRIPS reduced splenocyte number per spleen but Fe TBI. Fe TBI alone increased CAs significantly at 2.0 Gy but 0.1 Gy. Exposure to CRIPS alone didn’t induce CAs but concurrent exposure to CRIPS and Fe TBI showed a tendency of increase in the frequency of CAs as compared to exposure to Fe TBI alone, though the increases were not statistically significant. Further analyses are required to confirm the modification effects from CRIPS on Fe TBI-induced CAs. Acknowledgement: This work was partially supported by both the Ministry of Education, Culture, Sports, Science and Technology Grant-in-Aid for Scientific Research on Innovative Areas, Grant Numbers JP15K21745 and 5H05935 “Living in Space” and 3 HIMAC Research Project Grants (22B258, 14J286 and 16J295). | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 学会The 16th International Congress of Radiation Research (ICRR2019)に出席し、ポスター発表を行う。 タイトル:Effects of chronic restraint-induced stress and Fe-particle irradiation on induction of chromosomal aberrations in Trp53-heterozygous mice | |||||
| 発表年月日 | ||||||
| 日付 | 2019-09-26 | |||||
| 日付タイプ | Issued | |||||
