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Effect of irradiation time on biological effectiveness and tumor control probability in proton therapy
https://repo.qst.go.jp/records/76574
https://repo.qst.go.jp/records/76574d4d3687d-b55c-4585-ab1f-76a5bbf4d69b
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2019-08-27 | |||||
| タイトル | ||||||
| タイトル | Effect of irradiation time on biological effectiveness and tumor control probability in proton therapy | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Takei, Hideyuki
× Takei, Hideyuki× Inaniwa, Taku× Takei, Hideyuki× Inaniwa, Taku |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Purpose The biological effectiveness of proton beams may decrease with the irradiation time due to sublethal damage repair. The purpose of this study is to systematically evaluate this effect in hypofractionated proton therapy for various target sizes, depths and prescribed doses per fraction. Methods and materials Plans with single spread-out Bragg peak (SOBP) beam were created using a constant relative biological effectiveness (RBE) of 1.1 to cover the targets of six different sizes located at three different depths in water. Biological doses of 2, 3, 5, 10 and 20 Gy (RBE) were prescribed to the targets. First, to investigate the depth-variation of the biological effectiveness, the biological dose in instantaneous irradiation was recalculated based on the microdosimetric kinetic model (MKM). The sublethal damage repair (SLDR) was then taken into account in the MKM during treatments to obtain the irradiation-time-dependent biological effectiveness for the irradiation time T of 5-60 min and the beam interruption time τ of 0−60 min. The tumor control probabilities (TCPs) were calculated for single-fraction proton therapy fields of different Ts and τs, and the curative doses were evaluated at a TCP of 90%. Results The biological effectiveness decreased with longer T and τ, and higher prescribed dose. The maximum decrease in the biological effectiveness of the target was 21% with 20 Gy (RBE) prescribed dose. In single-fraction proton therapy, the curative dose increased approximately by 33%−35% linearly with the increase of T from 0 to 60 min. Conclusions The biological effectiveness varies largely with T and τ due to the SLDR during treatments. This effect was pronounced for high prescribed doses per fraction. Thus, the effect of the SLDR should be taken into account in hypofractionated and single-fraction proton therapies for any sizes and depths of the target. |
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| 書誌情報 |
International Journal of Radiation Oncology, Biology, Physics 巻 105, 号 1, p. 222-229, 発行日 2019-05 |
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| 出版者 | ||||||
| 出版者 | Elsevier | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0360-3016 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1016/j.ijrobp.2019.05.004 | |||||
| 関連サイト | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1016/j.ijrobp.2019.05.004 | |||||
