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Influence of a perpendicular magnetic field on biological effectiveness of carbon-ion beams
https://repo.qst.go.jp/records/76573
https://repo.qst.go.jp/records/7657358b19ec4-6092-45db-bed9-2f942035fa10
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2019-08-27 | |||||
| タイトル | ||||||
| タイトル | Influence of a perpendicular magnetic field on biological effectiveness of carbon-ion beams | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Inaniwa, Taku
× Inaniwa, Taku× Suzuki, Masao× Sato, Shinji× Noda, Akira× Muramatsu, Masayuki× Iwata, Yoshiyuki× Kanematsu, Nobuyuki× Shirai, Toshiyuki× Noda, Koji× Inaniwa, Taku× Suzuki, Masao× Sato, Shinji× Noda, Akira× Muramatsu, Masayuki× Iwata, Yoshiyuki× Kanematsu, Nobuyuki× Shirai, Toshiyuki× Noda, Koji |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Purpose: Our previous study revealed application of a magnetic field longitudinal to a carbon-ion beam of 0.1 ≤ B// ≤ 0.6 T enhances the biological effectiveness of the radiation. The purpose of this study is to experimentally verify whether application of a magnetic field perpendicular to the beam also alters the biological effectiveness. Methods and Materials: Most experimental conditions other than the magnetic field direction were the same as those used in the previous study to allow comparison of their results. Human cancer and normal cells were exposed to low (12 keV/μm) and high (50 keV/μm) linear energy transfer (LET) carbon-ion beams under the perpendicular magnetic fields of = 0, 0.15, 0.3, or 0.6 T generated by a dipole magnet. The effects of the magnetic fields on the biological effectiveness were evaluated by clonogenic cell survival. Doses that would result in the survival of 10%, D10s, were determined for the exposures and analyzed using Student’s t-tests. Results: For both cancer and normal cells treated by low- and high-LET carbon-ion beams, the D10s measured in the presence of the perpendicular magnetic fields of ≥ 0.15 T were not statistically different (p >> 0.05) from the D10s measured in the absence of the magnetic fields, = 0 T. Conclusions: Exposure of human cancer and normal cells to the perpendicular magnetic fields of ≤ 0.6 T did not alter significantly the biological effectiveness of the carbon-ion beams, unlike the exposure to longitudinal magnetic fields of the same strength. Although the mechanisms underlying the observed results still require further exploration, these findings indicate that the influence of the magnetic field on biological effectiveness of the carbon-ion beam depends on the applied field direction with respect to the beam. |
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| 書誌情報 |
International Journal of Radiation Biology 巻 95, 号 9, p. 1346-1350, 発行日 2019-06 |
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| 出版者 | ||||||
| 出版者 | Taylor and Francis | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0955-3002 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1080/09553002.2019.1625461 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.tandfonline.com/doi/full/10.1080/09553002.2019.1625461 | |||||
