WEKO3
アイテム
Radiogenomics Consortium Genome-Wide Association Study Meta-Analysis of Late Toxicity After Prostate Cancer Radiotherapy
https://repo.qst.go.jp/records/76566
https://repo.qst.go.jp/records/76566db2b55d4-9b41-46a8-9041-59290ea36376
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2019-08-26 | |||||
| タイトル | ||||||
| タイトル | Radiogenomics Consortium Genome-Wide Association Study Meta-Analysis of Late Toxicity After Prostate Cancer Radiotherapy | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
L. Kerns, Sarah
× L. Kerns, Sarah× Fachal, Laura× Dorling, Leila× C. Barnett, Gillian× Baran, Andrea× R. Peterson, Derick× Hollenberg, Michelle× Hao, Ke× Di Narzo, Antonio× Eren Ahsen, Mehmet× Pandey, Gaurav× Søren, M. Bentzen× Janelsins, Michelle× M. Elliott, Rebecca× D. P. Pharoah, Paul× G. Burnet, Neil× P. Dearnaley, David× L. Gulliford, Sarah× Hall, Emma× R. Sydes, Matthew× Miguel, E. Aguado-Barrera× Antonio, Gomez-Caamano× M. Carballo, Ana× Peleteiro, Paula× Ramon, Lobato-Busto× Stock, Richard× N. Stone, Nelson× Ostrer, Harry× Usmani, Nawaid× Singhal, Sandeep× Tsuji, Hiroshi× Imai, Takashi× Saito, Shiro× Eeles, Rosalind× DeRuyck, Kim× Parliament, Matthew× M. Dunning, Alison× Vega, Ana× S. Rosenstein, Barry× M. L.West, Catharine× Tsuji, Hiroshi× Imai, Takashi |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background: A total of 10%–20% of patients develop long-term toxicity following radiotherapy for prostate cancer. Identification of common genetic variants associated with susceptibility to radiotoxicity might improve risk prediction and inform functional mechanistic studies. Methods: We conducted an individual patient data meta-analysis of six genome-wide association studies (n=3871) in men of European ancestry who underwent radiotherapy for prostate cancer. Radiotoxicities (increased urinary frequency, decreased urinary stream, hematuria, rectal bleeding) were graded prospectively. We used grouped relative risk models to test associations with approximately 6 million genotyped or imputed variants (time to first grade 2 or higher toxicity event). Variants with two-sided Pmeta less than 5 X E-8 were considered statistically significant. Bayesian false discovery probability provided an additional measure of confidence. Statistically significant variants were evaluated in three Japanese cohorts (n=962). All statistical tests were two-sided. Results: Meta-analysis of the European ancestry cohorts identified three genomic signals: single nucleotide polymorphism rs17055178 with rectal bleeding (Pmeta = 6.2 X E-10), rs10969913 with decreased urinary stream (Pmeta = 2.9 X E-10), and rs11122573 with hematuria (Pmeta = 1.8 X E-8). Fine-scale mapping of these three regions was used to identify another independent signal (rs147121532) associated with hematuria (Pconditional = 4.7 X E-6). Credible causal variants at these four signals lie in gene-regulatory regions, some modulating expression of nearby genes. Previously identified variants showed consistent. |
|||||
| 書誌情報 |
Journal of the National Cancer Institute 巻 112, 号 2, p. djz075, 発行日 2019-05 |
|||||
| 出版者 | ||||||
| 出版者 | OXFORD | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0027-8874 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1093/jnci/djz075 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://academic.oup.com/jnci/advance-article/doi/10.1093/jnci/djz075/5490201 | |||||
