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Mast cells play role in wound healing through the ZnT2/GPR39/IL-6 axis
https://repo.qst.go.jp/records/76392
https://repo.qst.go.jp/records/76392b2241aad-bda2-4a31-809a-348b251f6ca5
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2019-07-31 | |||||
| タイトル | ||||||
| タイトル | Mast cells play role in wound healing through the ZnT2/GPR39/IL-6 axis | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Nishida, Keigo
× Nishida, Keigo× Hasegawa, Aiko× Yamasaki, Satoru× Uchida, Ryota× Ohashi, Wakana× Kurashima, Yosuke× Kunisawa, Jun× Kimura, Shunsuke× Iwanaga, Toshihiko× Watarai, Hiroshi× Hase, Koji× Ogura, Hideki× Nakayama, Manabu× Jun-Ichi, Kashiwakura× Okayama, Yoshimichi× Kubo, Masato× Ohara, Osamu× Kiyono, Hiroshi× Koseki, Haruhiko× Murakami, Masaaki× Hirano, Toshio× Hirano, Toshio |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Zinc (Zn) is an essential nutrient and its deficiency causes immunodeficiency and skin disorders. Various cells including mast cells release Zn-containing granules when activated; however, the biological role of the released Zn is currently unclear. Here we report our findings that Zn transporter ZnT2 is required for the release of Zn from mast cells. In addition, we found that Zn and mast cells induce IL-6 production from inflammatory cells such as skin fibroblasts and promote wound healing, a process that involves inflammation. Zn induces the production of a variety of pro-inflammatory cytokines including IL-6 through signaling pathways mediated by the Zn receptor GPR39. Consistent with these findings, wound healing was impaired in mice lacking IL-6 or GPR39. Thus, our results show that Zn and mast cells play a critical role in wound healing through activation of the GPR39/IL-6 signaling axis. | |||||
| 書誌情報 |
Scientific reports 巻 9, 号 1, p. 10842, 発行日 2019-07 |
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| 出版者 | ||||||
| 出版者 | Nature | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2045-2322 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 31346193 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1038/s41598-019-47132-5 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.nature.com/articles/s41598-019-47132-5 | |||||
