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Quantum Tools to Explore Radiobiological Effects on Living Systems
https://repo.qst.go.jp/records/76195
https://repo.qst.go.jp/records/76195a17db91b-ec48-4318-b906-99f3df173424
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2019-05-27 | |||||
| タイトル | ||||||
| タイトル | Quantum Tools to Explore Radiobiological Effects on Living Systems | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
横谷, 明徳
× 横谷, 明徳× Yokoya, Akinari |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | In several research projects on radiobiological effects promoted in a Japanese new research organization, National Institutes for Quantum and Radiological Science and Technology (QST), two quantum tools are mainly applied. The first one is quantum-sensing using single photon-emission crystals, namely NVC-diamond or Vsi-SiC. One of the research ideas is exploring thermal gradient in the cell exposed. Recently a few studies reported that temperature in a living cell was not uniform and significantly depends on the loci or organelles in the cell. We address a question whether ionizing irradiation causes further thermal gradient depending on DNA damage and its repair. These processes need to consume energies for fixing the damage resulting heat dissipation. Another quantum tool is high brilliant synchrotron radiation from accelerators. In addition to protein crystallography, recent technical advances allow particular electronic states of biological molecules to be targeted with high energy resolution. Typically evidences of the physicochemical processes involved in radiation damage to DNA have been accumulated. The use of spatially focused X-ray microbeams can target not only a whole single-cell, but also specific organelle level to observe cellular responses to irradiation. Circular dichroism (CD) measurements, as well as small angle X-ray scattering (SAXS), have also been applied to obtain structural aspects of non-crystallized biomolecules in solution or under biomimetic conditions. The structural changes caused by epigenetic modification, such as phosphorylation of proteins, are also potential targets for those experiments. We will overview the recent advances and questions addressed in those projects of QST. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | PhotonIcs& Electromagnetics Research Symposium | |||||
| 発表年月日 | ||||||
| 日付 | 2019-06-17 | |||||
| 日付タイプ | Issued | |||||
