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Stochastic Microdosimetric Kinetic model for hypo-fractionated multi-ion therapy
https://repo.qst.go.jp/records/76082
https://repo.qst.go.jp/records/76082ae13906e-8e7b-4caa-a9f9-6773f38bf56a
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2019-06-21 | |||||
| タイトル | ||||||
| タイトル | Stochastic Microdosimetric Kinetic model for hypo-fractionated multi-ion therapy | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Inaniwa, Taku
× Inaniwa, Taku× Suzuki, Masao× Kanematsu, Nobuyuki× Sung-Hyun, Lee× Tansho, Ryohei× Mizushima, Kota× Hara, Yousuke× Inaniwa, Taku× Suzuki, Masao× Kanematsu, Nobuyuki× Sung-Hyun, Lee× Tansho, Ryohei× Mizushima, Kota× Hara, Yousuke |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The microdosimetric kinetic (MK) model is a biological model used to predict cell-survival fractions from the specific energy absorbed by a microscopic subnuclear structure, domain, for various radiations. The MK model has been used in clinical treatments of carbon-ion radiotherapy at NIRS. While the MK model gives reasonable predictions in biological effectiveness of carbon-ion beams in most clinical cases, discrepancies were found between the calculated and measured cell-survival fractions for high-LET and high-dose irradiations. Recently, we have started a research project of a hypo-fractionated multi-ion therapy (HFMIT) for further developments of heavy-ion therapy. In HFMIT, the heavy ions up to neon ions are considered as the primary beams, i.e., high-LET radiations. In addition, the fractionated dose will be more than 10 Gy (RBE), i.e., high dose. Therefore, we developed a stochastic microdosimentric kinetic (SMK) model that can be used in treatment planning of HFMIT. In SMK mode, the stochastic natures of specific energies both in a domain and a cell nucleus are taken into account. The SMK model could reproduce the measured cell-survival fractions for high-LET and high-dose irradiations. The SMK model was integrated into our research treatment planning system, and tested in the in-vitro experiments of HSGc-C5 and MiaPaca2 cells exposed by scanned helium, carbon, oxygen and neon ion beams. The SMK model and developed computation method offer the accuracy and simplicity required in HFMIT of wide LET and dose ranges. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | PTCOG58 | |||||
| 発表年月日 | ||||||
| 日付 | 2019-06-13 | |||||
| 日付タイプ | Issued | |||||
