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Overexpression of Ras-related C3 botulinum toxin substrate 2 radiosensitizes melanoma cells in vitro and in vivo
https://repo.qst.go.jp/records/75967
https://repo.qst.go.jp/records/7596721cc24db-0d92-49fc-805e-ef4c937574b4
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2019-05-07 | |||||
| タイトル | ||||||
| タイトル | Overexpression of Ras-related C3 botulinum toxin substrate 2 radiosensitizes melanoma cells in vitro and in vivo | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Hu, Wentao
× Hu, Wentao× Zhu, Lin× Weiwei Pei× Pan, Shuxian× Guo, Ziyang× Wu, Anqing× Pei, Hailong× Nie, Jing× Li, Bingyan× Furusawa, Yoshiya× Konishi, Teruaki× K. Hei, Tom× Zhou, Guangming× Furusawa, Yoshiya× Konishi, Teruaki |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Radioresistance is the major obstacle in the radiotherapy of the malignant melanoma. Thus it is of importance to increase the radiosensitivity of melanoma cells. In present study, the radioresistant melanoma cell line OCM-1 with inducible over-expression of Ras-related C3 botulinum toxin substrate 2 was established based on radiation-inducible early growth response gene (Egr-1) promoter. The effects of Ras-related C3 botulinum toxin substrate 2 overexpression on the radiosensitivity of melanoma cells exposed to either X-rays or carbon ion beams were evaluated in cultured cells as well as xenograft tumor models. In addition, both reactive oxygen species yield and the NADPH oxidase activity were measured in the irradiated melanoma cells. It was found that the radiation-inducible overexpression of Ras-related C3 botulinum toxin substrate 2 sensitized the melanoma cells to both X-rays and carbon ion irradiation by enhancing the NADPH oxidase activity and the subsequent reactive oxygen species production. Besides, the overexpression of Ras-related C3 botulinum toxin substrate 2 enhanced the tumor-killing effect of radiotherapy in xenograft tumors significantly. The results of this study indicate that Ras-related C3 botulinum toxin substrate 2 is promising in increasing the radiosensitivity of melanoma cells, which provides experimental evidence and theoretical basis for clinical radiosensitization of the malignant melanoma. | |||||
| 書誌情報 |
Oxidative Medicine and Cellular Longevity 巻 2019, p. 5254798, 発行日 2019-05 |
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| 出版者 | ||||||
| 出版者 | Hindawi | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1942-0900 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 31281584 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1155/2019/5254798 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.hindawi.com/journals/omcl/2019/5254798/ | |||||
