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Analysis of SPICE microbeam size using fluorescent nuclear track detector (FNTD)
https://repo.qst.go.jp/records/75964
https://repo.qst.go.jp/records/759649b4cc154-f542-4ed9-9f10-a75259781e7e
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2019-06-03 | |||||
| タイトル | ||||||
| タイトル | Analysis of SPICE microbeam size using fluorescent nuclear track detector (FNTD) | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Ohsawa, Daisuke
× Ohsawa, Daisuke× Furusawa, Yoshiya× Kobayashi, Alisa× Oikawa, Masakazu× Konishi, Teruaki× Ohsawa, Daisuke× Furusawa, Yoshiya× Kobayashi, Alisa× Oikawa, Masakazu× Konishi, Teruaki |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Single Particle Irradiation system to Cell (SPICE) facility at the National Institute of Radiological Sciences (NIRS) provides a magnetically focused 3.4 MeV proton microbeam. Throughout the radiobiological studies using SPICE over the years, we have realized that biological effect can be affected by the highly localized dose distribution of the microbeam and results may differ from that of broad beam irradiation. Previously, we have reported that the beam size of the SPICE microbeam was approximately 2 μm in diameter; the proton traversal was identified as etch pits produced on plastic nuclear track detectors, CR-39. However, this widely used method cannot distinguish individual proton tracks of highly focused microbeam due to the overlapping of etch pits, which was major limitation for beam size analysis as well as estimation of localized dose distribution in the cells. To overcome this limitation, we used fluorescent nuclear track detectors (FNTD; Al2O3: C, Mg) to investigate the beam size and its proton-number dependence (7-1,000 protons per position). Detail analysis of Z(optical axis)-stacks of fluorescent images of the FNTD with a confocal laser scanning microscope clearly demonstrated that FNTDs has better spatial resolution and detection sensitivity compared to the conventional CR-39 detectors. The overall beam size was evaluated as elliptical shape or rectangular shape and determined to be in the range of 2.0 × 1.5 to 3.1 × 2.4 μm, depending on the number of protons per position. This result suggests that out-focused fraction of the incident protons contributes the broadening of the beam size. Throughout the present study, the FNTD irradiation and related image processing technology have demonstrated the feasibility of high-resolution measurement of the microbeam size over a wide range of the microbeam intensity. | |||||
| 書誌情報 |
Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms 巻 453, p. 9-14, 発行日 2019-06 |
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| 出版者 | ||||||
| 出版者 | Elsevier | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0168-583X | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1016/j.nimb.2019.05.019 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.sciencedirect.com/science/article/pii/S0168583X19303234 | |||||
