ログイン
言語:

WEKO3

  • トップ
  • ランキング
To
lat lon distance
To

Field does not validate



インデックスリンク

インデックスツリー

メールアドレスを入力してください。

WEKO

One fine body…

WEKO

One fine body…

アイテム

  1. 原著論文

BYSTANDER WI-38 CELLS MODULATE DNA DOUBLE-STRAND BREAK REPAIR IN MICROBEAM-TARGETED A549 CELLS THROUGH GAP JUNCTION INTERCELLULAR COMMUNICATION

https://repo.qst.go.jp/records/75842
https://repo.qst.go.jp/records/75842
fc2451b3-f454-4c79-93d8-bf6e54fab8f6
Item type 学術雑誌論文 / Journal Article(1)
公開日 2019-04-18
タイトル
タイトル BYSTANDER WI-38 CELLS MODULATE DNA DOUBLE-STRAND BREAK REPAIR IN MICROBEAM-TARGETED A549 CELLS THROUGH GAP JUNCTION INTERCELLULAR COMMUNICATION
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 Kobayashi, Alisa

× Kobayashi, Alisa

WEKO 914779

Kobayashi, Alisa

Search repository
Autsavapromporn, Narongchai

× Autsavapromporn, Narongchai

WEKO 914780

Autsavapromporn, Narongchai

Search repository
Ahbrizal Farizal Tengku Ahmad, Tengku

× Ahbrizal Farizal Tengku Ahmad, Tengku

WEKO 914781

Ahbrizal Farizal Tengku Ahmad, Tengku

Search repository
Oikawa, Masakazu

× Oikawa, Masakazu

WEKO 914782

Oikawa, Masakazu

Search repository
Shino, Homma-Takeda

× Shino, Homma-Takeda

WEKO 914783

Shino, Homma-Takeda

Search repository
Furusawa, Yoshiya

× Furusawa, Yoshiya

WEKO 914784

Furusawa, Yoshiya

Search repository
Wang, Jun

× Wang, Jun

WEKO 914785

Wang, Jun

Search repository
Konishi, Teruaki

× Konishi, Teruaki

WEKO 914786

Konishi, Teruaki

Search repository
Kobayashi, Alisa

× Kobayashi, Alisa

WEKO 914787

en Kobayashi, Alisa

Search repository
Oikawa, Masakazu

× Oikawa, Masakazu

WEKO 914788

en Oikawa, Masakazu

Search repository
Takeda, Shino

× Takeda, Shino

WEKO 914789

en Takeda, Shino

Search repository
Furusawa, Yoshiya

× Furusawa, Yoshiya

WEKO 914790

en Furusawa, Yoshiya

Search repository
Konishi, Teruaki

× Konishi, Teruaki

WEKO 914791

en Konishi, Teruaki

Search repository
抄録
内容記述タイプ Abstract
内容記述 Bi-directional signaling involved in radiation-induced bystander effect (RIBE) between irradiated carcinoma cells and their surrounding non-irradiated normal cells is relevant to radiation cancer therapy. Using the SPICE-NIRS microbeam, we delivered 500 protons to A549-GFP lung carcinoma cells, stably expressing H2B-GFP, which were co-cultured with normal WI-38 cells. The level of γ-H2AX, a marker for DNA double-strand breaks (DSB), was subsequently measured up to 24 h post irradiation in both targeted and bystander cells. As a result, inhibition of gap junction intercellular communication (GJIC) attenuated DSB repair in targeted A549-GFP cells, and suppressed RIBE in bystander WI-38 cells but not in distant A549-GFP cells. This suggests that GJIC plays a two-way role through propagating DNA damage effect between carcinoma to normal cells and reversing the bystander signaling, also called “rescue effect” from bystander cells to irradiated cells, to enhance the DSB repair in targeted cells.
書誌情報 Radiation Protection Dosimetry

巻 183, 号 1-2, p. 142-146, 発行日 2018-12
出版者
出版者 Oxford University Press
ISSN
収録物識別子タイプ ISSN
収録物識別子 0144-8420
DOI
識別子タイプ DOI
関連識別子 10.1093/rpd/ncy249
関連サイト
識別子タイプ DOI
関連識別子 https://doi.org/10.1093/rpd/ncy249
戻る
0
views
See details
Views

Versions

Ver.1 2023-05-15 17:52:44.567950
Show All versions

Share

Mendeley Twitter Facebook Print Addthis

Cite as

エクスポート

OAI-PMH
  • OAI-PMH JPCOAR 2.0
  • OAI-PMH JPCOAR 1.0
  • OAI-PMH DublinCore
  • OAI-PMH DDI
Other Formats
  • JSON
  • BIBTEX

Confirm


Powered by WEKO3


Powered by WEKO3