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A Novel SPECT Tracer for Cerebral Amyloid and Tau Aggregates Accumulated in Alzheimer's Disease and related tauopathy
https://repo.qst.go.jp/records/75830
https://repo.qst.go.jp/records/75830232674aa-4aca-44c7-a420-c09f095424b3
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2019-04-26 | |||||
| タイトル | ||||||
| タイトル | A Novel SPECT Tracer for Cerebral Amyloid and Tau Aggregates Accumulated in Alzheimer's Disease and related tauopathy | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Bin Ji
× Bin Ji× Chie Seki× Sahara, Naruhiko× Chun-Jen, Chen× Ashino, Hiroki× Fujimoto, Osuke× Nakahara, Yuto× Shiraishi, Hideaki× Matsushima, Satoshi× Oshikiri, Shinobu× Ono, Maiko× Minamihisamatsu, Takeharu× Suhara, Tetsuya× Higuchi, Makoto× Ji, Bin× Seki, Chie× Sahara, Naruhiko× Chun-Jen, Chen× Ono, Maiko× Minamihisamatsu, Takeharu× Suhara, Tetsuya× Higuchi, Makoto |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | BACKGROUND: Non-invasive determination for amyloid- (A) plaques and neurofibrillary tangles (NFTs) has important significance for early diagnosis and medical intervention to Alzheimer’s disease (AD) and related tauopathies. Although several single photon emission computed tomography (SPECT) tracers for Aplaques imaging were reported, to the best of our knowledge, no tracer is successful for tau imaging in the living brains. PURPOSE: In the present study, we have developed a novel SPECT tracer AD-DRK for A and tau deposition for in-vivo detection. METHODS: 125I-labeled AD-DRK ([125I] AD-DRK) was designed and synthesized based on our previous publication. The biodistribution was determined in normal mice. The detectability of Ab and tau deposition was investigated by in-vitro and ex-vivo autoradiography in APP and tauopathy mouse models, and post-mortem human brains. RESULTS: [125I] AD-DRK showed high initial brain uptake with a peak value of approximately 7% of injection dose per ml at 2 minute post-injection and rapid washout thereafter. In vitro autoradiography has clearly demonstrated that there was overt specific binding of [125I] AD-DRK in temporal cortex region of AD or progressive supranuclear palsy (PSP) enriched with A plaques and/or neurofibrillary tangle. Moreover, ex vivo autoradiographic analysis showed that [125I] AD-DRK has higher accumulation in forebrain enriched with A or tau accumulation in AD and tauopathy mouse models compared with normal mouse, implying the utility of AD-DRK for in-vivo imaging for A and/or tau deposition. CONCLUSION: [125I] AD-DRK has demonstrated high potential as SPECT ligand for diagnosis for AD and/or related tauopathies. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | THE 13TH ASIA OCEANIA CONGRESS OF NUCLEAR MEDICINE AND BIOLOGY | |||||
| 発表年月日 | ||||||
| 日付 | 2019-05-11 | |||||
| 日付タイプ | Issued | |||||
