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Monte Carlo investigation of the characteristics of radioactive beams for heavy ion therapy
https://repo.qst.go.jp/records/75781
https://repo.qst.go.jp/records/75781e99ca517-2685-4102-80b3-c4e17aa5ee59
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2019-05-09 | |||||
| タイトル | ||||||
| タイトル | Monte Carlo investigation of the characteristics of radioactive beams for heavy ion therapy | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Chacon, Andrew
× Chacon, Andrew× Safavi naeini, Mitra× Bolst, David× Guatelli, Susanna× R. Franklin, Daniel× Iwao, Yuma× Akamatsu, Go× Tashima, Hideaki× Yoshida, Eiji× Nishikido, Fumihiko× Kitagawa, Atsushi× Mohammadi, Akram× Marie-Claude, Gregoire× Yamaya, Taiga× B. Rosenfeld, Anatoly× Chacon, Andrew× Safavi naeini, Mitra× Iwao, Yuma× Akamatsu, Go× Tashima, Hideaki× Yoshida, Eiji× Nishikido, Fumihiko× Kitagawa, Atsushi× Mohammadi, Akram× Yamaya, Taiga |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | This work presents a simulation study evaluating relative biological effectiveness at 10% survival fraction (RBE10) of several different positron-emitting radionuclides in heavy ion treatment systems, and comparing these to the RBE10s of their non-radioactive counterparts. RBE10 is evaluated as a function of depth for three positron-emitting radioactive ion beams (10C, 11C and 15O) and two stable ion beams (12C and 16O) using the modified microdosimetric kinetic model (MKM) in a heterogeneous skull phantom subject to a rectangular 50 mm × 50 mm × 60 mm spread out Bragg peak. We demonstrate that the RBE10 of the positron-emitting radioactive beams is almost identical to the corresponding stable isotopes. The potential improvement in PET quality assurance image quality which is obtained when using radioactive beams is evaluated by comparing the signal to background ratios of positron annihilations at different intra- and post-irradiation time points. Finally, the incidental dose to the patient resulting from the use of radioactive beams is also quantified and shown to be negligible. | |||||
| 書誌情報 |
Scientific Reports 巻 9, 号 6537, 発行日 2019-05 |
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| 出版者 | ||||||
| 出版者 | Nature Publishing Group | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2045-2322 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1038/s41598-019-43073-1 | |||||
| 関連サイト | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1038/s41598-019-43073-1 | |||||
