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Optimizing intensity modulated particle therapy via rational combination of physical and biological approaches (17J420-FY2018)
https://repo.qst.go.jp/records/75684
https://repo.qst.go.jp/records/7568469593c0b-3aee-4dce-8bd3-13a1d117195d
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2019-04-18 | |||||
| タイトル | ||||||
| タイトル | Optimizing intensity modulated particle therapy via rational combination of physical and biological approaches (17J420-FY2018) | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Sawakuchi, Gabriel
× Sawakuchi, Gabriel× McFadden, Conor× Flint, David× Bright, Scott× Chakraborty, S.× Grosshans, D.R.× Mohan, R.× Furusawa, Yoshiya× Kodaira, Satoshi× Konishi, Teruaki× Satoshi, Kodaira× Teruaki, Konishi |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The goal of this project is to evaluate the role of deficiencies in DNA repair pathways on particle therapy (PT) response. We have exposed five cell lines (M059J, M059K, H1299, H460 and BxPC-3) to 6 MV x-rays, protons (100 MeV: 1.1, 2.5 and 7.8 keV/µm), He-ions (150 MeV/u: 2.2, 6.9 and 13.4 keV/µm) and C-ions (290 MeV/u: 13.5, 28.1 and 61.4 keV/µm) for clonogenic cell survival assessment. The response of the cell lines were then characterized in terms of the relative biological effectiveness (RBE). Here we presented updated values of the RBE of these cell lines, which ranged from 0.90-1.70 for protons, 0.87-1.30 for He-ions, and 1.11-1.97 for C-ions. Our data on RBE indicated that different cell lines respond widely differently to PT beams. We further demonstrated that DNA repair deficiencies play a major role in the response of cell lines to PT beams. Particularly, our data suggest that non-homologous end joining repair has a major role in repairing radiation induced DNA lesions. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 平成30年度放射線医学総合研究所 重粒子線がん治療装置等共同利用研究報告書 | |||||
| 発表年月日 | ||||||
| 日付 | 2019-04-22 | |||||
| 日付タイプ | Issued | |||||
