WEKO3
アイテム
Effect of 5-Fluorouracil on cellular response to proton beam in esophageal cancer cell lines according to the position of Spread-Out Bragg Peak
https://repo.qst.go.jp/records/75528
https://repo.qst.go.jp/records/755281a6d2490-28a7-4b69-a6f6-49f5d77c2abc
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2019-04-02 | |||||
| タイトル | ||||||
| タイトル | Effect of 5-Fluorouracil on cellular response to proton beam in esophageal cancer cell lines according to the position of Spread-Out Bragg Peak | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Hojo, Hidehiro
× Hojo, Hidehiro× Dohmae, Takeshi× Hotta, Kenji× Shun-ichiro, Kageyama× Baba, Hiromi× 河野, 良介× Motegi, Atsushi× Tsuchihara, Katsuya× Akimoto, Tetsuo× Kohno, Ryosuke |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Introduction: To investigate enhancement by 5-fluorouracil (5-FU) of the sensitivity of cancer cells to proton beam irradiation and clarify the differences in the responses of the 5-FU-treated cells to proton beam irradiation according to the position of the cells on the spread-out Bragg peak (SOBP). Methods: OE21 human esophageal squamous cells were irradiated with a 235-MeV proton beam at four different positions on the SOBP. The effects of the irradiation plus 5-FU treatment on the cell sur- vival were assessed by clonogenic assays and determination of the sensitizer enhancement ratio (SER). In addition, DNA double-strand breaks were estimated by measuring phospho-histone H2AX (cH2AX) foci formation in the cells at 0.5 and 24 h after irradiation. Results: The relative biological effectiveness (RBE) of proton beam irradiation against vehicle-control cells tended to increase with an increase in the depth of the cells on the SOBP. On the other hand, the degree of enhancement of the cellular sensitivity to proton beam irradiation by 5-FU was similar across all the positions on the SOBP. Furthermore, a marked increase in the number of residual cH2AX foci at 24 h post-irradiation was observed in the cells at the distal end of the SOBP. Conclusions: Our data indicated that the degree of enhancement by 5-FU of the sensitivity of OE21 cells to 235-MeV proton beam irradiation did not differ significantly depending on the position of the cells on the SOBP. Furthermore, the degree of increase in the number of cH2AX foci at 24 h after pro- ton beam irradiation with or without 5-FU exposure did not differ significantly according to the pos- ition on the SOBP. The effect of 5-FU in enhancing the effect of proton beam irradiation on cancer cells may be constant for all positions on the SOBP. |
|||||
| 書誌情報 |
ACTA ONCOLOGICA 巻 58, 号 4, p. 475-482, 発行日 2019-01 |
|||||
| 出版者 | ||||||
| 出版者 | Taylor&Francis | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0284-186X | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1080/0284186X.2018.1555373 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.tandfonline.com/doi/full/10.1080/0284186X.2018.1555373 | |||||
